C20. Common CV Drugs Flashcards
name some anti cholesterol drugs
statins
fibrates
PCSK9 inhibitors
siRNA of PCSK9
give me an example of a statin
simvastatin
what do statins do
block HMG CoA reductase
when are statins used
hypercholesterolaemia
diabetes
angina/MI
CVA/TIA
if you are high risk of MI / CVA
what are some side effects of statins
myalgia/myopathy
Rhabdomyolysis (rarely)….renal failure
what is a fibrate
medication that lowers triglycerides and increase HDL
give me an example of a fibrate
bezafibrate
when would you use fibrates
when you are hypertriglyceridemia or have low HDL cholesterol
if you have familial hypercholesterolaemia, statins might not be enough. What would you take instead?
PCSK9 inhibitors
give 2 examples of PCSK9 inhibitors
alirocumab
evolocumab
how do PCSK9 inhibitors work
inhibit the binding of PCSK9 to LDL receptorshen PCSK9 is blocked, more LDL receptors are available to remove LDL from the blood, which helps lower LDL-C levels.
what kind of drug is Inclisiran
small interfering RNA (siRNA)
how do siRNA work
turns of/silences the PCSK9 gene which helps the liver remove harmful cholesterol from the blood
is hypertension silent/asymptomatic or presents with lots of symptoms
asymptomatic
what is the ABCD anagram for hypertension drugs
A - ACE inhibitors/ARBs
B- Beta blockers
C- Calcium antagonists
D- Diuretics esp Thiazide Diuretic
if there is resistance or the patient can’t use these drugs for hypertension. Which drugs can they use…
Alpha blocker- doxazosin
spironolactone
Moxonidine
what is the antihypertensive sequence of drugs if the patient is 55 or under
start with ACEi / ARB
then CCB the Diuretic then spironolactone then B blocker
what is the antihypertensive sequence of drugs if the patient is over 55
start with CCB then ARB/ACEi then spironolactone the BBlocker
