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First Year med - dundee > C20. Common CV Drugs > Flashcards

C20. Common CV Drugs Flashcards

1
Q

name some anti cholesterol drugs

A

statins
fibrates
PCSK9 inhibitors
siRNA of PCSK9

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2
Q

give me an example of a statin

A

simvastatin

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3
Q

what do statins do

A

block HMG CoA reductase

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4
Q

when are statins used

A

hypercholesterolaemia
diabetes
angina/MI
CVA/TIA
if you are high risk of MI / CVA

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5
Q

what are some side effects of statins

A

myalgia/myopathy
Rhabdomyolysis (rarely)….renal failure

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6
Q

what is a fibrate

A

medication that lowers triglycerides and increase HDL

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7
Q

give me an example of a fibrate

A

bezafibrate

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8
Q

when would you use fibrates

A

when you are hypertriglyceridemia or have low HDL cholesterol

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9
Q

if you have familial hypercholesterolaemia, statins might not be enough. What would you take instead?

A

PCSK9 inhibitors

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10
Q

give 2 examples of PCSK9 inhibitors

A

alirocumab
evolocumab

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11
Q

how do PCSK9 inhibitors work

A

inhibit the binding of PCSK9 to LDL receptorshen PCSK9 is blocked, more LDL receptors are available to remove LDL from the blood, which helps lower LDL-C levels.

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12
Q

what kind of drug is Inclisiran

A

small interfering RNA (siRNA)

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13
Q

how do siRNA work

A

turns of/silences the PCSK9 gene which helps the liver remove harmful cholesterol from the blood

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14
Q

is hypertension silent/asymptomatic or presents with lots of symptoms

A

asymptomatic

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15
Q

what is the ABCD anagram for hypertension drugs

A

A - ACE inhibitors/ARBs
B- Beta blockers
C- Calcium antagonists
D- Diuretics esp Thiazide Diuretic

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16
Q

if there is resistance or the patient can’t use these drugs for hypertension. Which drugs can they use…

A

Alpha blocker- doxazosin
spironolactone
Moxonidine

17
Q

what is the antihypertensive sequence of drugs if the patient is 55 or under

A

start with ACEi / ARB
then CCB the Diuretic then spironolactone then B blocker

18
Q

what is the antihypertensive sequence of drugs if the patient is over 55

A

start with CCB then ARB/ACEi then spironolactone the BBlocker

19
Q
A

First Year med - dundee (54 decks)

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