Female reproductive Flashcards
1
Q
What is the principle organ for estrogen and progesterone production in the female?
A
Ovaries
2
Q
How many tissue layers are in the uterus? Name them.
A
- Serous 2. Muscular 3. Mucous
3
Q
What layer of the uterus is shed?
A
The mucous (endometirum) layer
4
Q
What is the specialization found on the fallopian tubes that aid in oocyte/sperm movement?
A
Cilia
5
Q
What are the two hypothalamic peptide hormones that play a role in female reproduction?
A
GnRH Oxytocin
6
Q
What are the three pituitary hormones that play a role in female reproduction?
A
FSH LH Prolactin
7
Q
What is the ovarian peptide hormones that inhibits the female reproductive cycle?
A
Inhibi
8
Q
What are the four ovarian steroid hormones?
A
Estradiol Progesterone Androstenedione Testosterone
9
Q
What ion causes the release of peptide hormone to be release from vesicle?
A
Ca
10
Q
Are peptide hormones lipophilic or hydrophilic?
A
Hydrophilic
11
Q
Do peptide hormones circulate freely, or bound to stuff?
A
Freely
12
Q
Where in/on the cell do peptide hormones exert their effects?
A
On the cell membrane, binding to cell surface receptors
13
Q
What are the two types of cell membrane receptors for peptide hormones?
A
Receptor protein tyrosine kinases G-coupled protein receptors
14
Q
Steroid hormones are derived from what molecule?
A
Cholesterol
15
Q
Are steroid hormones lipophilic or hydrophilic?
A
Lipophilic
16
Q
How do steroid hormones circulate: bound or not?
A
Bound
17
Q
What are the enzymes that synthesize estradiol from androstenediones?
A
Aromatases
18
Q
Draw out the cholesterol pathway for steroid synthesis.
A
***
19
Q
Where are the receptors found for steroid hormones? What happens when they are bound?
A
Cytosol–binding leads to movement to nucleus to upregulate DNA
20
Q
Hormone duration in circulation is largely dependent on what?
A
Binding protein in the blood
21
Q
What are the two principle sites of degradation of steroid hormones?
A
At the site of action Liver
22
Q
How are steroid hormones degraded in the liver? (board question)
A
Conjugated via glucuronidation and sulfation to increase hydrophilicity (don’t need to know this for this test)
23
Q
What are the two ways steroid hormones are excreted?
A
in the bile or in the urine
24
Q
What does estrogen do in the uterus? (3)
A
- Increases size 2. Proliferate endometrium 3. Develop of endometrial glands
25
What is the effect of estrogen on ovaries and the vagina?
Increase in size
26
What is the effect of estrogen on the external sex organs?
Deposition of fat
27
What are the effects of estrogen on the fallopian tubes? (2)
Develop glandular tissue Increased epithelial cells
28
What are the two major effects of estrogen on the skeleton?
Inhibits osteoclastic activity, Unites epiphyses of long bones
29
What effect does estrogen have on Na/water retention?
Increases
30
What is the effect of estrogen on the cervical mucus? Progesterone?
Thin and stringy = estrogen Thick = progesterone
31
What are the three effects of progesterone on the uterus?
1. Promotes the secretory changes of the endometium 2. Decreases frequency of uterine contraction 3. Decreased prostaglandin production
32
What is the effect of progesterone on fallopian tubes?
Secretion of nutrients
33
What happens to the number of oogonia as a female reaches puberty?
goes down significantly
34
What is the oocyte that is present until reproductive years? Is this a diploid or haploid?
Primary oocyte--diploid
35
In what phase of meiosis is the primary oocyte in?
Prophase I
36
What is the gamete yield per oocyte in males? Females?
4 for males 1 for females
37
What is an ootid?
The egg before differentiation
38
What is chromosomal wastage?
Formation of polar bodies by the females gametogenesis
39
What is the primordial follicle?
A layer of \*\*granulosa\*\* cells that surround the primary oocyte
40
What is the hormones that granulosa cells secrete in the primordial follicle?
Maturation inhibiting factor
41
What is a primary follicle?
Oocyte + additional layers of granulosa cells
42
What stimulate the development of a primary follicle?
LH/FSH\*\*\*
43
What is the hormone that promotes the secretion of FSH and LH from the pituitary?
GnRH
44
What are the three hormones that are secreted by the gonads that play a role in female reproductive development?
Estrogen Progesterone Inhibins
45
What are the two hormones released from the anterior pituitary in response to GnRH?
FSH and LH
46
What is the feedback mechanism on the HPA in female reproduction? What type is this (ultra short, short, or long)?
Estrogen Progesterone Inhibins This is a long feedback regulation
47
Is the feedback mechanism for females negative or positive?
Mixed
48
What is the average duration of the female monthly sexual cycle?
28 days
49
What are the two phases of the monthly sexual cycle?
Follicular phase Luteal phase
50
What happens during the follicular phase of the ovarian cycle?
1. follicle development 2. Endometrial proliferation 3. oulation
51
GnRH is release in what fashion?
Pulsatile
52
LH is release from the anterior pituitary how often?
About every 90 minutes
53
During the follicular phase, what type of feedback does estrogen exert? Where is this direceted?
Negative feedback at the ant pituitary and hypothalamus
54
Do LH and FSH levels ever go down to 0?
no
55
When is positive feedback occur with estrogen?
At mid cycle, just prior to ovulation
56
What type of feedback occurs in the luteal phase with estrogen? What does this do?
Negative--shuts down LH and FSH production
57
What are the cells that secrete inhibin B?
Granulosa cells
58
What is the effect of inhibin?
Exerts negative feedback on the HPA
59
When does inhibin B secretion spike?
Just after ovulation
60
What happens to [inhibin B] during the follicular phase?
medium levels
61
What happens to the inhibin A in the luteal phase?
Secreted from the corpus luteum, inhibits gonadotropin secretion
62
When cells secrete inhibin A?
Corpus luteum
63
What are the cells that produce androstenedione in response to LH?
Theca cells
64
Androstenedione is converted to what by granulosa cells? What is this controlled by?
Estradiol Controlled by FSH
65
Theca cells synthesize androstenedione in response to what hormone? Where does this androstenedione go?
LH Androstenedione goes to the Granulosa cells, where it is converted to estradiol
66
What type of feedback occurs during the follicular phase with estrogen secretion?
Negative, but not completely inhibitory
67
Which hormone (LH or FSH) rises markedly during the follicular phase? What does this cause?
FSH Causes granulosa cell proliferation Develops theca cells
68
There are two types of theca cells. What are the theca cells that form the capsule of the follicle, and which are the hormone producing ones?
Theca externa = capsule Theca interna = secrete hormone
69
Increased steroid production from the theca cells is regulated by what hormones?
LH and FSH
70
What happens to FSH receptor expression in granulosa cells in response to estradiol secretion?
Increased FSH sensitivity and more follicular secretion
71
What increases the expression of LH receptors on theca cells?
Estradiol
72
What are the hormones that cause the proliferation of thecal cells?
LH and estradiol
73
How many follicles mature fully? What happens to the others that were growing?
One. Others die.
74
What happens when FSH declines in terms of follicular development?
Demise of immature follicles
75
What happens to the endometrium during the follicular phase?
Endometrial proliferation
76
What promotes the proliferation of the epithelial cells of the uterus and the other endometrial growth stuff?
estrogen
77
At mid cycle, what happens to estrogen production? What causes this?
Increases markedly, caused by positive feedback
78
What is absolutely required for ovulation?
Surge in LH
79
What stimulates the rupture of the follicle?
LH
80
What is the best marker for ovulation? Why?
Progesterone because it increases basal body temperature
81
What is the corpus luteum formed from?
Thecal, granulosa, fibroblasts, etc.
82
What hormones does the corpus luteum secrete?
Estradiol and progesterone
83
LH/ hCG stimulates theca cells to produce what? What happens to this hormone?
androstenedione--goes to the granulosa-lutein cell, to make estradiol
84
What are LDL receptors upregulated on granulosa-lutein cells?
Need cholesterol for progesterone synthesis
85
What are the cells that produce progesterone in the luteal phase?
Granulosa-lutein cells
86
Development and differentiation of the endometrium during the luteal phase is mediated by what hormone?
Progesterone
87
What is the progestational phase or secretory phase of the endometrial cycle?
When endometrium develops in the luteal phase
88
What are the endometrial changes seen in the luteal phase?
Increased vasculature and deposition of nutrients
89
What is the hormone that really shuts down anterior pit secretion of LH/FSH during the luteal phase?
Inhibin A
90
What causes the loss of steroids seen in the luteal phase?
Loss of corpus luteum
91
What is the effect of progesterone on smooth muscle contraction? Prostaglandin production?
Suppresses
92
What causes the release of proteolytic enzymes in the menstrual phase?
Decline in estrogen and progesterone
93
Increases prostaglandin prodution in the mentrual phase causs what?
Contraction
94
When the steroid production falls in the menstrual cycle, what happens to LH and FSH? WHy?
Rise d/t loss of negative feedback
95
What is the barrier that sperm must get through to fertilize the egg?
zona pellucida
96
What allows a blastocyst to invade the endometrium?
Enzyme secretion
97
What prevents that decline in LH/steroids with implantation of the blastocyst?
hCG released
98
What does the corpus luteum secrete to inhibit myometrial contractions?
Relaxin
99
After week 8 maintenance of the pregnancy is no longer supported by the corpus luteum, but by what?
The placenta
100
Plot out the summary slide.
101
What causes the transition to puberty?
Increased pulsatile release of GnRH at night, leading to increased estrogen synthesis
102
What causes the onset of menopause?
Loss of estradiol and inhibin d/t loss of follicles
103
What happens to LH and FSH during menopause? Why?
Elevation d/t a loss of negative feedback
104
Does estrogen production stop completely during menopause? Why or why not?
No, adipose tissue can still produce
105
What causes the rise in FSH and LH in the mid follicular phase?
development of the theca cells and granulosa cells
106
When FSH declines in the follicular phase, what does this cause?
Death of all but one follicle
107
What causes the decline in FSH in the mid follicular phase?
Inhibin B
108
What are the cells that secrete inhibin B?
Granulosa cells
109
What causes the increase epithelialization of the uterus during the follicular phase?
Estrogen
110
What causes the increase in estradiol synthesis at the midpoint of menstruation?
Increased sensitivity of the granulosa/theca cells to FSH/LH
111
What does the surge in estrogen cause?
The surge in FSH and LH
112
What is the hormone that is ABSOLUTELY needed for ovulation?
LH
113
Is there much progesterone in the body prior to the onset of the luteal phase?
Not much
114
What happens to the concentrations of FSH and LH in the mid luteal phase? Why?
Decreases due to progesterone and inhibin A secretion
115
What causes the corpus luteum to die if there is no implantation?
Loss of LH/FSH due to negative feedback by progesterone and inhibin A
116
What causes puberty?
Onset of nocturnal secretion of FSH/LH
117
What causes menopause?
Apoptosis of follicular cells, and resulting decrease in estrogen synthesis
118
What happens to [LH] and [FSH] during menopause? Why?
Increase since there is less estrogen to provide feedback inhibition
