Renal and Endocrine cases

Question 1

What happens to ACTH produced by the pituitary in the presence of dexamethasone? What about an ectopic ACTH production?

Answer 1

Reduce if pituitary, no ACTH reduction if ectopic

Question 2

What would happen to ACTH if the MC2R receptor did not function?

Answer 2

Higher, because there is no cort synthesis

Question 3

What is the MOA of amenorrhea with cushings?

Answer 3

Cort inhibits CRH production in the hypotahlamus

Question 4

What happens to insulin sensitivity in Cushing’s?

Answer 4

Decreases due to chronic elevated BG levels

Question 5

What is the effect of Cort on aldosterone?

Answer 5

Increases d/t enzyme saturation of 11beta-HSD2

Question 6

How does Cushing’s cause HTN?

Answer 6

Aldosterone synthesis

Question 7

Why osteoporosis with Cushings?

Answer 7

Cort inhibits osteoblasts

Question 8

What is the main control of prolactin?

Answer 8

Dopamine (inhibits it)

Question 9

What are the two major chemicals that the prostate releases into the ejaculatory duct?

Answer 9

PSA

bicarb

Question 10

What are the two major chemicals that the seminal vesicles release into the ejaculatory duct?

Answer 10

Fibrinogen and fructose

Question 11

What does inhibin B repress in the male?

Answer 11

FSH

Question 12

What is the other name for thyroxine-binding prealbumin?

Answer 12

Transthyretin

Question 13

What is the other name for thyrotropin?

Answer 13

TSH