Digestion & Metabolism 2: LA Peritoneal Dz Flashcards

1
Q

clinical signs of peritoneal can be WHAT?

what are 3 common clinical signs?

A

VARIABLE, can look very different always

3 common?
1. GENERALIZED DULLNESS
2. GENERALIZED DEPRESSION
3. SECONDARY ILEUS

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2
Q

4 diagnostics for PERITONEAL dz?

which one is MOST IMPORTANT for diagnosis?

A
  1. PE/HISTORY
  2. HEMATOLOGY for signs of INFECTION, INFLAMMATION
  3. US of ABDOMEN for PERITONEAL FLUID
  4. ABDOMINOCENTESIS & SAMPLING –> MOST IMPORTANT FOR DIAGNOSIS OF PERITONEAL DZ
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3
Q

ABDOMINOCENTESIS..

what COLOR & CELL COUNT is normal?

what cells can NORMALLY be found in here? (2)

A

normal?
COLOR = CLEAR YELLOW
CELL COUNT = <5,000 cells/uL

a FEW LEUKOCYTES & MESOTHELIAL CELLS can be found

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4
Q

describe abdominal fluid color

A

NORMAL PERITONEAL FLUID, CLEAR YELLOW

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5
Q

what do MESOTHELIAL CELLS do?

what if we see A LOT of them upon ABDOMINOCENTESIS?

A

they MAKE UP THE PERITONEAL LINING

if TOO MANY = REACTIVE, potential inflammation

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6
Q

are PLANT MATERIAL, NEUTROPHILS or LYMPHOCYTES normal in peritoneal fluid?

A

NO

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7
Q

Dx what kind of peritonitis this is & what we can see!

A

SEPTIC PERITONITIS

can see EXTRA- and INTRACELLULAR BACTERIA

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8
Q

Dx what kind of peritonitis this is & what we can see!

A

SEPTIC PERITONITIS with REACTIVE MESOTHELIAL CELLS & WBCs

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9
Q

Dx what kind of peritonitis this is & what we can see in TOP & BOTTOM box?

A

this is ENTEROCENTESIS (from GI)

in TOP = PROTOZOA, indicates LEAKAGE FROM LI/COLON

in BOTTOM = MIXED BACTERIA

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10
Q

found in PERITONEAL FLUID, what is this? is it normal?

A

PLANT MATERIAL & NO

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11
Q

Dx what kind of peritonitis this is & what we can see! (see 2 things)

do we see any bacteria?

A

PANCREATITIS or BILE PERITONITIS

we can see…
1. can see REACTIVE but NON-DEGENERATE NEUTROPHILS & MACROPHAGES
2. LIPID VACUOLES consistent with FAT NECROSIS or CHYLE

NO BACTERIA

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12
Q

what is the MOST COMMON DISEASE OF THE PERITONEAL CAVITY IN LA?

A

BACTERIAL PERITONITIS

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13
Q

BACTERIAL PERITONITIS…

PRIMARY = ?

SECONDARY usually from…
& what do we see on CULTURE?

how is DIAGNOSIS CONFIRMED? does this rule out peritonitis?

A

PRIMARY = IDIOPATHIC

SECONDARY = CONTAMINATION OF PERITONEAL CAVITY FROM ANOTHER SOURCE (GI, REPRODUCTIVE, URINARY TRACT)

on culture, can see 1 or 2 PREDOMINATING bacteria

diagnosis CONFIRMED = >20,000 cells/uL, but DOES NOT RULE OUT PERITONITIS IF NOT

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14
Q

PRIMARY peritonitis occurs mainly in what 2 species?

A

HORSES & ALPACAS

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15
Q

PRIMARY peritonitis…

occurs in WHAT 2 SPECIES?

caused by WHAT organism in horses?

present with what 4 clinical signs?

see WHAT on US?

see WHAT on cytology?

what 3 CBC findings?

tx?

A

HORSES & ALPACAS

caused by ACTINOBACILLUS EQUUILLI most commonly

present with..
1. FEVER
2. ANOREXIA
3. DULL MENTATION
4. MILD COLIC

see INCREASED PERITONEAL FLUID ON US

3 CBC?
1. LEUKOCYTOSIS
2. HYPERFIBRINOGENEMIA
3. ELEVATED TS

tx = ANTIMICROBIALS

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16
Q

PRIMARY peritonitis…

occurs in WHAT 2 SPECIES?

caused by WHAT organism in ALPACAS?

prognosis?

A

HORSES & ALPACAS

in ALPACAS, caused by STREP. ZOOEPIDEMICUS (GRAM POSITIVE COCCI)

prognosis is GOOD with ANTIMICROBIALS

17
Q

what is the MOST COMMON FORM OF PERITONITIS?

chronicity of this condition?

A

SECONDARY PERITONITIS

often ACUTE

18
Q

SECONDARY peritonitis…

= usually as a result of WHAT?

causes WHAT 2 SEVERE clinical signs?

what OTHER clinical sign can we see & from what dz?

range of when this becomes FATAL? intervention?

fatality depends on…

A

= usually as a result of ACUTE, SEVERE RUPTURE OF GI TRACT

causes SEVERE INFLAMMATION & ENDOTOXEMIA

can also see INJECTED MMs from ENDOTOXEMIA

becomes fatal within 4-24 HOURS WITH OR WITHOUT INTERVENTION

fatality depends on HOW BIG THE LEAKAGE IS

19
Q

4 COMMON GI SOURCES of SECONDARY PERITONITIS in HORSES

A
  1. GASTRIC IMPACTION or STRANGULATING LESION
  2. CECAL IMPACTION causing RUPTURE
  3. LARGE COLON RUPTURE due to SEVERE COLITIS or MULTIPLE ENTEROLITHS
  4. SMALL COLON RUPTURE
20
Q

4 COMMON GI SOURCES of SECONDARY PERITONITIS in RUMINANTS

A
  1. RUMEN (from sx)
  2. RETICULUM (hardware dz)
  3. ABOMASAL ULCERATION/C3 ULCERATION
  4. STRANGULATION
21
Q

ACUTE GI RUPTURE has WHAT sort of prognosis?

what 2 conditions must be met to attempt intervention?

A

prognosis = GRAVE TO FATAL

2 conditions…
1. SOURCE OF CONTAMINATION CAN BE ADDRESSED
2. contamination can be METICULOUSLY DEBRIDED/LAVAGED

22
Q

CHRONIC SECONDARY PERITONITIS…

= usually presents how?

can be associated with what 4 conditions?

what is the MOST IMPORTANT part of TREATING THIS? what 3 ways can we achieve this?

A

= usually presents as a SLOW LEAK where INFLAMMATION/INFECTION occurs

can be associated with…
1. GI ISCHEMIA, NECROSIS & TRANSLOCATION
2. METASTATIC ABSCESSATION
3. TRAUMA via PENETRATION OF ABDOMINAL CAVITY
4. UMBILICAL REMNANT ABSCESS

we need to FIND THE SOURCE!! we can do that by..
1. HEMATOLOGY
2. COMPREHENSIVE ABDOMINAL US
3. EXPLORATORY Sx

23
Q

SEPTIC PERITONITIS should be treated via…

what approach should be used for EQUIDS/PIGS?

what approach should be used for RUMINANTS/CAMELIDS/PIGS?

what MUST BE DONE during procedure? (2)

A

SURGICAL EXPLORATION!

equids/pigs = VENTRAL MIDLINE under GA

ruminants/camelids/pigs = RIGHT FLANK under GA

we MUST DO A THOROUGH ABDOMINAL LAVAGE and ASPIRATE ALL THE FLUID LEFT THERE

24
Q

4 TREATMENTS for SEPTIC PERITONITIS

hint: support (2), antibiotics, pain

A
  1. CARDIOVASCULAR support via FLUIDS, COLLOIDS & VASOPRESSORS
  2. INCISIONAL SUPPORT w/ BANDAGE to AVOID SURGICAL SITE INFECTIONS
  3. SYSTEMIC ANTIMICROBIALS
  4. ANALGESIA/ANTI-INFLAMMATORIES
25
Q

PROGNOSIS for SEPTIC peritonitis…

overall?

3 specific examples?

A

OVERALL VARIABLE

3 examples?
1. GROSS GI RUPTURE = grave
2. SECONARY & ABLE TO CONTROL SOURCE = fair to good
3. PRIMARY PERITONITIS = good to excellent

26
Q

HEMOPERITONEUM…

clinical signs usually related to WHAT 2 PROBLEMS?

fever?

A

clinical signs usually related to…
1. DECREASED OXYGEN CARRYING CAPACITY
2. HYPOVOLEMIA

NO FEVER!!

27
Q

why should we assess BOTH PCV and TS when trying to determine if a horse has a HEMORRHAGE?

what other 2 CBC findings can indicate hemorrhage?

A

because horses have ENORMOUS SPLEENS with HUGE RBC RESERVES that can be stimulated by STRESS/SYMPATHETIC NS

but TS will START TO DECREASE IN HEMORRHAGE

2 others?
1. LACTATE INCREASES with ANAEROBIC METABOLISM (less O2)
2. CREATININE INCREASES/AZOTEMIA due to DECREASED RENAL PERFUSION

28
Q

what source of abdominal hemorrhage is COMMON IN NEONATES?

A

UMBILICAL VESSEL HEMORRHAGE and RETRACTION

29
Q

what source of abdominal hemorrhage is often associated with TRAUMA?

A

SPLEEN HEMORRHAGE

30
Q

diagnosis of HEMOPERITONEUM? (five)
+ findings for 2?

A
  1. CLINICAL SIGNS
  2. CBC –> PCV, TS, LACTATE, CREATININE
  3. US –> see SMOKE-LIKE MARKINGS IN FLUID
  4. ABDOMINOCENTESIS
  5. RECTAL exam to help RULE IN OR OUT REPRODUCTIVE or GI DZ
31
Q

FLUID treatment for HEMOPERITONEUM?

TRANSFUSIONS for HEMOPERITONEUM….

3 other meds?

A

FLUID tx must be CAUTIOUS given IV to provide CARDIOVASCULAR SUPPORT & NO BOLUSES

TRANSFUSIONS for HEMOPERITONEUM VERY RARELY USED IN LA

3 other meds?
1. ANALGESIA
2. ANTIMICROBIALS depending on WHY they’re bleeding
3. ANTIFIBRINOLYTIC/PRO-COAGULANT AGENTS