Defense & Barriers 1: Cytokines

Question 1

IL-1beta,alpha

Answer 1

produced by monocytes & other cell types

function = pro inflammatory, fever

Question 2

IL-2

Answer 2

produced by T cells

function = T cell growth factor

Question 3

IL-4

Answer 3

produced by Th2 cells, mast cells, basophils

function = B cell growth factor, promotes Th2 cells, IgE isotope, induces alternatively activated macrophages

Question 4

IL-5

Answer 4

produced by Th2 cells

function = eosinophil growth factor

Question 5

IL-6

Answer 5

produced by T cells & other cell types

function = proinflammatory

Question 6

IL-10

Answer 6

produced by T cells & macrophages

function = anti-inflammatory, inhibits T cell and macrophage function

Question 7

IL-12

Answer 7

produced by dendritic cells & macrophages

function = stimulates NK cells and T cells to make interferon-gamma

Question 8

IL-13

Answer 8

produced by T cells

function = induces alternatively activated macrophages

Question 9

IL-15

Answer 9

produced by T cells and epithelial cells

function = T cell growth factor

Question 10

IL-17

Answer 10

produced by T cells

function = pro inflammatory, increases neutrophil recruitment

Question 11

IFN-gamma

Answer 11

produced by Th1, NK and CD8 T cells

function = activates macrophages, upregs MHC class 2, promotes IgG2a class Abs

Question 12

TNF (tissue necrosis factor)

Answer 12

produced by macrophages, T cells, & many other cell types

function = proinflammatory

Question 13

TGF-beta

Answer 13

produced by macrophages, T cells, & many other cell types

function = increases IgA, inhibits immune responses, promotes wound healing and Treg cells

Question 14

IFN-alpha,beta

Answer 14

produced by many cells

function = anti-viral cytokine

Question 15

IL-21

Answer 15

produced by T cells

function = important for Tfh help for B cells

Question 16

IL-31

Answer 16

produced by T cells (Th2) & many other cell types

function = proinflammatory