[60] Cellular Signaling Pathways Flashcards

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1
Q

What are Cellular Signaling Pathways?

A

They are communication systems that coordinate cellular activities and enable cells to respond to environmental cues.

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2
Q

Name the basic elements of a cellular signaling pathway.

A
  • Ligand
  • Receptor
  • Transduction mechanism
  • Response
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3
Q

What is a ligand in the context of cellular signaling?

A

It’s a molecule that binds to a specific site on a receptor.

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4
Q

What is a receptor in the context of cellular signaling?

A

It’s a protein that receives the signal from a ligand.

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5
Q

What is transduction in cellular signaling?

A

It’s the process of converting the signal into a cellular response.

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6
Q

What is a second messenger in cellular signaling?

A

It’s a molecule that relays signals received at receptors on the cell surface.

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7
Q

Can you name a common second messenger?

A

Cyclic AMP (cAMP)

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8
Q

What does cAMP stand for?

A

Cyclic Adenosine Monophosphate

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9
Q

Name an example of a cellular signaling pathway.

A

The MAPK/ERK pathway

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10
Q

What does MAPK/ERK stand for?

A

Mitogen-Activated Protein Kinase/Extracellular Signal-Regulated Kinase

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11
Q

What role does the MAPK/ERK pathway play in the cell?

A

It regulates cell division, differentiation, and survival.

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12
Q

What is a kinase in the context of cellular signaling?

A

It’s an enzyme that adds a phosphate group to a protein in a process called phosphorylation.

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13
Q

What is the role of phosphorylation in cellular signaling?

A

It’s a key mechanism for regulating protein function and transmitting signals within the cell.

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14
Q

What is an antagonist in the context of cellular signaling?

A

It’s a molecule that inhibits the function of a receptor.

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15
Q

What is an agonist in the context of cellular signaling?

A

It’s a molecule that activates a receptor.

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16
Q

How does cellular signaling contribute to disease?

A

Abnormalities in signaling pathways can lead to uncontrolled cell growth or division, contributing to diseases like cancer.

17
Q

What is the potential therapeutic application of understanding cellular signaling pathways?

A

Targeting specific elements in a pathway can be used to design drugs for diseases.

18
Q

Can you name a drug that targets a cellular signaling pathway?

A

Trastuzumab (Herceptin) targets the HER2 receptor in breast cancer.

19
Q

What does HER2 stand for?

A

Human Epidermal growth factor Receptor 2