[40] Tissue Engineering and Organoids Flashcards
What is Tissue Engineering?
The practice of combining scaffolds, cells, and biologically active molecules into functional tissues.
What are the key elements of Tissue Engineering?
- Scaffolds
- Cells
- Biologically Active Molecules
What is the primary goal of Tissue Engineering?
To assemble functional constructs that restore, maintain, or improve damaged tissues or whole organs.
What are Organoids?
3D structures derived from stem cells that have organ-like features.
What is the significance of Organoids in research?
They can mimic the structure and function of human organs, enabling studies of organ development, disease, and treatment.
How are Organoids created?
By culturing stem cells in a 3D environment with specific growth factors.
What are some applications of Tissue Engineering?
- Repair or replace portions of or whole tissues (e.g., bone, cartilage, blood vessels)
- Bioengineer tissues for in vitro drug testing
What makes scaffolds important in Tissue Engineering?
They provide a template for tissue regeneration, guiding the growth of new tissue.
What are some challenges in Tissue Engineering?
- Ensuring biocompatibility and avoiding immune response
- Achieving proper functionality and integration with the body
How do Organoids help in personalized medicine?
Organoids can be generated from patient-derived cells, allowing for personalized disease modeling and drug testing.
What is the role of Biologically Active Molecules in Tissue Engineering?
They signal cells to behave in certain ways, influencing their growth and differentiation.
How do Organoids contribute to the understanding of human development?
They can recapitulate some aspects of organ development, providing insights into the processes that drive human development.
How are Organoids and Tissue Engineering related?
Organoids can be seen as an application of tissue engineering techniques, used to create miniature organ-like structures.
What type of cells are typically used in Tissue Engineering?
Stem Cells, due to their potential to differentiate into various cell types.
Why is 3D culture important for Organoid formation?
It allows cells to interact in all directions, similar to how they would in actual organs.
