[43] Drug Discovery and Design Flashcards
What is Drug Discovery?
The process through which potential new medicines are identified.
What is Drug Design?
An inventive process of finding new medication based on the knowledge of a biological target.
What are the main stages in drug discovery?
- Target identification
- Target validation
- Lead compound identification
- Lead optimization
Define Target Identification in drug discovery.
It’s the process of identifying a molecule or pathway whose modulation might lead to a therapeutic effect.
Define Target Validation in drug discovery.
It’s the process of demonstrating that this molecule or pathway can be a suitable drug target.
What is a Lead Compound in drug discovery?
A compound with medicinal properties that can be used as a template to develop more effective drugs.
What does Lead Optimization involve in drug discovery?
It involves chemical modifications to the lead compound to enhance its properties as a drug.
How is drug design related to drug discovery?
Drug design helps in the discovery process by designing new drugs based on the understanding of biological targets.
What is the role of bioinformatics in drug design?
It aids in the understanding of the molecular aspects of diseases and the identification of drug targets.
What is In Silico drug design?
A technique that uses computer modeling in the drug design process.
What does ADME stand for in drug design?
Absorption, Distribution, Metabolism, and Excretion
Why is ADME important in drug design?
It predicts how a drug will behave in the body, which is crucial in drug design.
What is Pharmacodynamics in drug design?
It’s the study of what the drug does to the body.
What is Pharmacokinetics in drug design?
It’s the study of what the body does to the drug.
How does Structure-Activity Relationship (SAR) aid in drug design?
It helps in understanding the relationship between a drug’s chemical structure and its pharmacological activity.
What is SAR?
Structure-Activity Relationship
What is High Throughput Screening in drug discovery?
It’s a method for scientific experimentation especially used in drug discovery for screening large numbers of biological modulators and effectors against selected targets.
How does computational chemistry contribute to drug design?
It uses computer simulations to assist in solving chemical problems, including drug design.
What is the role of medicinal chemistry in drug design?
It involves the design and synthesis of therapeutic agents, and the study of their interactions with biological targets.
What are the roles of biological targets in drug discovery?
They are the key to understanding the pathophysiology of diseases and are the basis for drug design.
