[47] Pathway Analysis and Functional Genomics Flashcards
What is Pathway Analysis?
The study of the ways in which different components of a system interact to affect the system’s overall function.
What is Functional Genomics?
The study of the relationship between an organism’s genome and its phenotype.
What is the primary goal of Functional Genomics?
To understand the roles and interactions of genes and proteins in a biological system.
How does Pathway Analysis contribute to Functional Genomics?
It helps identify networks of genes or proteins that interact to perform a biological function, which can provide insight into the functional role of individual genes.
What are the primary tools used in Pathway Analysis?
Bioinformatics software and databases that contain information about known biological pathways and interactions.
What are some applications of Functional Genomics?
- Disease research
- Drug discovery
- Bioengineering
- Agriculture
How does Functional Genomics differ from traditional genomics?
Traditional genomics focuses on sequencing and mapping of the genome, while functional genomics focuses on understanding the function of genes and their interactions.
What are some methods used in Functional Genomics?
- Gene knockouts
- RNA interference
- Transcriptomics
- Proteomics
Define the term “Gene Knockout”.
A genetic technique in which one of an organism’s genes is made inoperative.
What is RNA interference?
A biological process where RNA molecules inhibit gene expression.
How does Proteomics contribute to Functional Genomics?
By studying the function and interaction of proteins (the products of genes), it can provide insight into gene function.
How can Pathway Analysis contribute to disease research?
It can identify disrupted pathways in diseases, which can be targets for therapeutic interventions.
What is a Biological Pathway?
A series of actions among molecules in a cell that leads to a certain product or a change in the cell.
How can Functional Genomics contribute to personalized medicine?
By understanding the function of genes and their variations in individuals, it can inform the development of personalized treatment strategies.
What role does bioinformatics play in Pathway Analysis?
It provides the tools and methods needed to analyze and visualize complex pathway data.
What are some challenges of Functional Genomics?
Some challenges include the complexity of biological systems, the large scale of genomic data, and the difficulty of linking genotype to phenotype.
Define the term “Phenotype”.
The observable physical properties of an organism, including its morphology, development, biochemical or physiological properties, behavior, and products of behavior.
Define the term “Genotype”.
The genetic makeup of an organism or group of organisms with reference to a single trait, set of traits, or an entire complex of traits.
How can Pathway Analysis be used in drug discovery?
It can identify target pathways that can be modulated by drugs to treat diseases.
What is Bioengineering?
The application of concepts and methods of biology to solve real-world problems related to life sciences or the application thereof, using engineering’s own analytical and synthetic methodologies.
