[07] Proteomics and Protein-Protein Interaction Networks Flashcards
What is Proteomics?
Large-scale study of proteomes, which are sets of proteins produced in an organism, system, or biological context.
What are Protein-Protein Interaction Networks?
Interactions among proteins forming complex networks that provide insights into cellular processes and functions.
What techniques are used in Proteomics?
- Mass spectrometry
- Two-dimensional gel electrophoresis.
Why is Proteomics important?
- Discovery of new proteins
- Understanding of disease mechanisms
- Identification of drug targets
- Understanding organism’s response to stimuli.
What are the challenges in Proteomics?
- High complexity and dynamic nature of proteomes
- Sensitivity of detection
- Distinguishing between similar proteins.
How does Proteomics contribute to the understanding of cellular processes?
By studying protein interactions and networks, proteomics can provide insights into how cellular processes and functions are regulated.
What is the role of Protein-Protein Interaction Networks in disease understanding?
They can help to identify disease mechanisms by revealing altered protein interactions and functions in disease conditions.
How can Proteomics lead to the discovery of new proteins?
By using techniques like mass spectrometry to identify and quantify proteins, new proteins can be discovered.
What is the role of Proteomics in drug discovery?
It can help to identify potential drug targets by revealing the proteins involved in disease mechanisms.
How does Proteomics help in understanding an organism’s response to stimuli?
By studying changes in protein expression and interaction in response to stimuli, proteomics can provide insights into how an organism responds to different conditions.
Why is the high complexity and dynamic nature of proteomes a challenge in Proteomics?
Because proteomes can contain thousands of different proteins that can change rapidly in response to different conditions, they are highly complex and dynamic, which can make them difficult to study.
Why is sensitivity of detection a challenge in Proteomics?
Because many proteins are present in very low quantities, detecting and quantifying them accurately can be a challenge.
Why is distinguishing between similar proteins a challenge in Proteomics?
Because many proteins are very similar in structure and function, distinguishing between them accurately can be a challenge.
