[59] Epitranscriptomics Flashcards
What is Epitranscriptomics?
It’s the study of RNA modifications and their role in gene expression regulation.
How does epitranscriptomics differ from epigenetics?
While both involve modifications, epigenetics is about DNA and histone modifications, while epitranscriptomics deals with RNA modifications.
Name a common type of RNA modification studied in epitranscriptomics?
N6-methyladenosine (m6A)
What does m6A stand for?
N6-methyladenosine
What role does m6A modification play in RNA function?
It influences various aspects of RNA metabolism, including stability, splicing, transport, and translation.
What is RNA metabolism?
It refers to the various processes that maintain RNA quality and quantity, like synthesis, modification, degradation, and others.
What is an “RNA modification writer”?
An enzyme that adds a modification to the RNA molecule.
Can you name an example of an RNA modification writer?
Methyltransferase-like 3 (METTL3)
What does METTL3 stand for?
Methyltransferase-like 3
What is an “RNA modification eraser”?
An enzyme that removes a modification from the RNA molecule.
Can you name an example of an RNA modification eraser?
Fat mass and obesity-associated protein (FTO)
What does FTO stand for?
Fat mass and obesity-associated protein
What is an “RNA modification reader”?
A protein that recognizes and binds to the modified RNA, affecting its function.
Can you name an example of an RNA modification reader?
YTH domain-containing family protein (YTHDF)
What does YTHDF stand for?
YTH domain-containing family protein
