29. Anesthesiology Flashcards
A drug which, when applied “locally” in a concentration without toxic effects, reversibly blocks the conduction of nerve impulses (*both sensory and motor)
Local anesthetics
Action of local anesthetics: Blocks what?
Blocks sodium channels preventing depolarization (intracellular)
Injectable form of local anesthesia
Ionized form or Water soluble
Unionized free base form
Lipid soluble
Aka “acid dissociation constant”
Determines acidity of compound (ability to donate protons)
pKa
aka “power of hydrogen”
pH
pKa is aka
Acid dissociation constant
Lidocaine pKa = 7.8
pH = 7.8 (basic)
Ionized 💦:
Unionized:
Lidocaine pKa = 7.8
pH = 7.8 (basic)
Ionized 💦: 50%
Unionized: 50%
Lidocaine pKa = 7.8
pH = 4 (acidic)
Ionized 💦:
Unionized:
Lidocaine pKa = 7.8
pH = 4 (acidic)
Ionized 💦: >50%
Unionized: <50%
- kaya di nageeffect ung anes pag may infection
Lidocaine pKa = 7.8
pH = 10 (more basic)
Ionized 💦:
Unionized:
Lidocaine pKa = 7.8
pH = 10 (more basic)
Ionized 💦: <50%
Unionized: >50%
BQ: Order of Loss of Sensation
“PaT ToPS”
(“PaT ToPS”) Pain Temperature Touch Pressure Skeletal muscle tone
Increase dosage of anesthesia in bloodstream
Toxicity
Toxicity:
Toxicity:
✅Rapid induction of LA
✅Vessel deposition
✅Over dosage
Maximum number of carpules
7
Overdosage effects:
CNS-
Cardiac-
CNS: Anxiety
Heart: ⬇️fxn of heart > ⬇️blood to brain ➡️ Syncope
BQ: Most common medical emergency in the dental clinic
Syncope
Management of syncope
Trendelenburg position
H1 receptor : Bronchoconstriction and vasodilation
Examples of H1 blocker?
Diphenhydramine
Cetirizine
Loratadin
H2 - sTWOmach = ⬆️gastric sec = pain
Examples of H2 blockers?
Cemetidine
Ranitidine
Preservative of LA
- prevents contamination from microbes
Methylparaben
BQ: Antioxidant of vasoconstrictors (reducing agent)
Sodium bisulfites
Sa boards iniiba lang spelling ng “bisulfites”
Ester has highest incidence of LA allergic reaction because of
PABA (similar to methylparaben)
Bacteriostatic Drug that mimics PABA (⬆️allergy)
Sulfonamides
Most common vasoconstrictor
Epinephrine
BQ: Most impt function of vasoconstrictors?
Increase duration of effect of LA
BQ: What is the maximum dosage of vasoconstrictors for NORMAL Patients?
0.2mg or 200mcg
BQ: What is the max dosage of vasoconstrictors for CARDIOVASCULAR COMPROMISED patients?
0.04mg or 40mcg
Maximum number of cartridges given to CARDIOVASCULAR COMPROMISED patients
2 cartridges
BQ: What is the max number of LA carpule for AVERAGE pxs?
7 carpules
BQ: True or False. All local anesthetics are vasoCONSTRICTORS.
False!
[All LAs are vasoDILATORS]
#except: Cocaine (vasoconstrictor)
LA with vasoconstrictor or epinephrine is contraindicated to pxs with
Hyperthyroidism ❌
✅hypertension
BQ: 2% Lidocaine with 1:100,000 epi = 1.8ml
Mg of lidocaine?
20mg x 1.8ml = 36mg lidocaine