Viral skin Flashcards
What are the three major skin ailments due to viruses?
- Papillomas
- Ulcers/purulent lesions
- Childhood rash and fever
What are the two viruses that cause papillomas/nodules?
HPV and molluscum
What are the three viruses that cause ulcers/purulent lesions?
Herpes
Chicken pox
Small pox
What are the four viral causes of childhood rash and fever?
Measles
German measlses
Roseola
Fifth disease
How are skin infections via viruses infected?
Virus infects other systems, causes viremia
Viruses direct infection of the skin
What are the two types of skin lesions caused by viruses? What causes them?
Infectious and noninfectious
Infex = viral replication
Non-infex = immune response
What is a papilloma?
Benign growth on the surface of the skin or mucous membrane
Hyperkeratosis, and koilocytes, are found with what skin lesion?
Warts
Are cutaneous warts painful?
Generally not
What is the virus that causes warts?
HPV
What are verruca vulgaris? How do these appear?
Common warts
Rough, cauliflower on hands and feet
What are verruca plantaris? How do these appear?
Plantar warts
Grows inward, appears as only thickened keratin layer with punctate hemorrhages
What are verruca plana? How do these appear?
Facial warts, smooth
What is the virus family of HPV? Genome? enveloped?
papovaviridae
Non-enveloped
dsDNA
What cell layer actually has virions in them in HPV infections?
Suprabasal layer
What cell layer become infected by virions in HPV infections?
Basal layer of the epidermis
What are the histological characteristics of a wart relative to normal skin? What causes this?
Each layer is expanded d/t increased virus signal to grow
What are the two cell proteins that activate the cell cycle? How does each do its thing?
HPV E7 and E6
E6 inhibits p53
E7 inhibits Rb
How are viral HPV classified?
Mucosal(anogenital)
Cutaneous (common and plantar)
How are warts transmitted?
Direct contact with a wart or contaminated surface
What specific surface is particularly prone to transmit warts?
Non-slip shower mats
How do you diagnose warts?
Clinical appearance
Koloidal cells
How do Koilocytes appear?
Nucleus surrounded by a halo of unstained section
How do you treat plantar warts? (3)
Cryotherapy
Cytotoxic chemicals
Surgical removal
What are the HPV strains that cause high risk angogenital warts?
16
18
31
33
What are the HPV strains that cause low risk angogenital warts?
6
11
What are the HPV strains that cause plantar warts?
1
4