Skinny viral II

Question 1

What are the symptoms of smallpox?

Answer 1

ILI

Enanthem and Exanthem (lesions)

Question 2

What body parts are smallpox rashes seen on? What is distinct about the evolution, relative to other rashes like chickenpox?

Answer 2

Mouth (enanthem stage)

Palms and soles, body (exanthem stage)

There is a synchronous evolution of lesions

Question 3

What is the causative agent of smallpox? Family? Genome?

Answer 3

Variola virus

Poxviridae family
dsDNA

Question 4

What is the distribution of the small pox rash?

Answer 4

Centrifugal distribution

Question 5

What type of rash is smallpox?

Answer 5

Firm vesicles to pustules

Question 6

Where does variola virus replicate?

Answer 6

in cytoplasm

Question 7

How is smallpox transmitted? (3)

Answer 7

Contact with lesion
Fomites
air in close spaces

Question 8

How long are individuals considered infectious with smallpox?

Answer 8

Until all scabs have separated from lesions (a monthish)

Question 9

What are the complications of smallpox? (2) Fatality rate?

Answer 9

death (30%)
Arthritis
Encephalitis

Question 10

What does the smallpox vaccine contain?

Answer 10

Live strain of vaccinia virus

another poxvirus

Question 11

What are the complications of the smallpox vaccine?

Answer 11

Eczema vaccinatum

death

Question 12

What is the difference in distribution of smallpox vs chickenpox?

Answer 12

Smallpox = centrifugal (limbs > trunk)

Chickenpox = centripetal (trunk > limbs)

Question 13

What is the evolution difference between smallpox and chickenpox?

Answer 13

Smallpox has synchronous lesions

Not for the chicken

Question 14

What is the treatment for smallpox?

Answer 14

vaccination

Question 15

What is rubeloa?

Answer 15

Another name for Measles

Question 16

What is the rash seen in measles? How does it start/spread?

Answer 16

Maculopapular

Starts from head, down

Question 17

What are the four prodrome symptoms of measles?

Answer 17

Cough
Coryza
Conjunctivitis
Koplik spots

Question 18

What is the family of measles virus? Genome? Enveloped? How many types?

Answer 18

Paramyxovirus
-ssRNA
Enveloped
One type

Question 19

What is the gene that measles virus has the allows for fusion?

Answer 19

F protein

Question 20

How is measles transmitted?

Answer 20

Respiratory droplets

Question 21

How contagious is measles? Why?

Answer 21

Very because can live in air for 2 hours

Question 22

How do you clinically diagnose measles? (2)

Answer 22

Koplik spots + characteristic rash >3 days,

Question 23

What are koplik spots?

Answer 23

White macule with a red border on the mucosa of the mouth next to the molars. Prodrome for measles.

Question 24

What are the severe complications with measles? (3)

Answer 24

Encephalitis
Pneumonia
Szs

Question 25

What is the treatment for measles?

Answer 25

IG within 6 days

Question 26

What are the four pieces of evidence for measles resistance?

Answer 26

1. Documented vaccination 2. Lab evidence of immunity 3. Documentation of past diagnosis 4. Born before 1957

Question 27

What two things need to be done for measles cases?

Answer 27

Lab verification | CDC report

Question 28

What does the measles vaccine contain?

Answer 28

Live attenuated | Combined in MMR(V)

Question 29

How is the measles vaccine prepared?

Answer 29

Chick embryo

Question 30

Dosage for measles vaccination?

Answer 30

First at one year | Second at 4-6 years

Question 31

What is the rash of German measles? How is this different from measles (3)?

Answer 31

Maculopapular rash on the face and spreading downward No coalescence Fainter color Lower fever

Question 32

What causes German Measles?

Answer 32

Rubella virus

Question 33

What are the symptoms of German measles?

Answer 33

Rash Arthralgias ILI

Question 34

What are the congenital complications of German measles?

Answer 34

Congenital deafness, cataracts, glaucoma,

Question 35

What are the symptoms of congeital rubella syndrome (3)?

Answer 35

Purpura (blueberry muffin baby) Hepatosplenomegaly/jaundice Microcephaly

Question 36

What is the family of the rubella virus? Genome? Enveloped?

Answer 36

Togaviridae Enveloped +ssRNA

Question 37

How is german measles transmitted?

Answer 37

Nasal secretinos

Question 38

How do you diagnose German measles?

Answer 38

Culture from tissue samples Serology

Question 39

What does the rubella vaccine contain? How is it made?

Answer 39

Live attenuated | Grown in tissue cultures

Question 40

What is the goal of vaccinating against german measles?

Answer 40

Reduce congenital Rubella syndrome

Question 41

What are the symptoms of fifth disease (erythema infectiosum)?

Answer 41

Fever | Rash beginning on the cheeks

Question 42

What causes fifth's disease (erythema infectiosum/slack cheek syndrome)?

Answer 42

B19 parvovirus

Question 43

What is the family, genome, for B19 virus?

Answer 43

Paroviridae | ssDNA

Question 44

What cells does the B19 virus grow in?

Answer 44

Mitotically active cells, usually in hematopoietic cells in bone marrow

Question 45

Who is affected most by B19 virus? What does this cause?

Answer 45

Pts with chronic anemia, causes Aplastic crisis

Question 46

What are the pregnancy complications of B19 infx?

Answer 46

Anemia CHF Hydrops fetalis

Question 47

What are the symptoms of Roseola infantum? Who is usually infected?

Answer 47

High fever, THEN maculopapular rash in an infant

Question 48

What causes Roseola infantum? family? genome? Enveloped?

Answer 48

HHV-6 or 7 herpesviridae dsDNA Enveloped?

Question 49

Where/what cells does HHV-6 replicate? (3)

Answer 49

T cell, B cells, and oropharynx

Question 50

Which cells does HHV-7 replicate in?

Answer 50

CD4 T cells

Question 51

How is Roseola transmitted?

Answer 51

Saliva

Question 52

Koplik spots = ?

Answer 52

Measles

Question 53

What is the function of the HA protein that measles produces?

Answer 53

Attachment

Question 54

What are the symptoms of fifth's disease?

Answer 54

Rash over the cheeks that spreads downward

Question 55

True or false: infection with the B19 virus (fifth's disease) is self limiting

Answer 55

True

Question 56

Lacelike distribution of rash = ?

Answer 56

B19 parvovirus (slap-cheek syndrome/fifth's disease/erythema infectiosum)

Question 57

Infant fever for 4-5 days, followed by a 1-2 maculopapular rash = ?

Answer 57

Roseola