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Pharmacology > Thyroid Drugs > Flashcards

Thyroid Drugs Flashcards

1
Q

Enzyme used to concert iodide ion to iodine

A

Thyroid peroxidase

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2
Q

Refers to the process where tyrosine residues in the thyroglobulin are iodinated to form MIT or DIT

A

Iodine organification

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3
Q

process where 2 molecules of DIT is combined to form T4 or 1 MIT to 1 DIT to form T3

A

coupling

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4
Q

T3 and T3 are released from the thyroid are transported by ____

A

Thyroxine-binding globulin

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5
Q

peripheral conversion refers to what process

A

T4 converted to T3 in target cells

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6
Q

what is the half life of T4?

A

7 days

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7
Q

in terms of volume of distribution, T4 vs T3

A

T4

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8
Q

Which is more potent?

T4 vs T3

A

T3

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9
Q

[Guess the drug]

cause myxedema coma

A

levothyroxine

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10
Q

What are the biologic effects of thyroid hormones?

A
  1. Brain maturation
  2. Bone growth
  3. Beta-adrenergic effects
  4. Basal metabolic rate increase
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11
Q

[Guess the drug]

inhibit thyroid peroxidase reaction, inhibit peripheral conversion of T4

causes fulminant hepatitis, agranulocytosis

A

PTU

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12
Q

What is the drug of choice for pregnant hyperthyroid patients?

A

PTU

preferable during the first trimester of pregnancy

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13
Q

[Guess the drug]

inhibits thyroid peroxidase reactions; blocks iodine organification

Causes agranulocytosis

A

methimazole

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14
Q

What is the DOC for non-pregnant hyperthyroid?

A

methimazole

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15
Q

Can cause aplasia cutis congenita

A

methimazole

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16
Q

Can cause choanal atresia of and esophageal atresia

A

methimazole

17
Q

inhibit iodine organification and hormone release; to reduce vascularity of thyroid gland

acts by thyroglobulin hydrolysis

A

KISS

18
Q

prevents radiation-induction thyroid damage

A

KISS

19
Q

[what phenomenon]

ingestion of iodine causes hypothyroidism

A

Wolf-chaikoff

20
Q

[what phenomenon]

ingestion of iodine causes hyperthyroidsm

A

Jod-Basedow

21
Q

[What drug]

Control HR, slows pacemaker, inhibit peripheral conversion

beta blocker

A

propranolol

22
Q

beta blockerthat can be used to treat thyrotoxicosis-related arrythmia

A

esmolol

23
Q

[What drug]

cause clinical improvement without altering the thyroid hormone level

A

propranolol

24
Q

Which drugs inhibit peripheral conversion of T4 to T3?

A
  1. Propylthiouracil
  2. Propranolol
  3. Hydrocortisone
25
Q

What drugs canc ause drug-induced hyperthyroidism?

A
  1. Clofibrate
  2. Amiodarone
  3. Methadone
26
Q

What is the DOC for amiodarone induced thyroid disease?

A

levothyroxine

Pharmacology (35 decks)

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