Hematopoeitic Growth Factors

Question 1

[Hematopoietic growth factor]

given once a week

Answer 1

darbepoetin

Question 2

[Hematopoietic growth factor]

given 1-2x per month

Answer 2

Methoxy Polyethelyn Glycol - Epoetin beta

Question 3

This drug acts as an agonist of erythropoeitin receptorss

Answer 3

Epoetin alfa

Question 4

what is the main stimulus of EPO release in the kidney?

Answer 4

hypoxia-inducible factor 1

Question 5

[Myeloid growth factor]

drug of choice for neutropenia associated with chemotherapy

Answer 5

filgastrim (GCSF)

Question 6

drug that mobilize peripheral blood cells in preparation for hematopoietic stem cell transplantation

Answer 6

filgastrim

Question 7

Cite examples of megakaryocyte growth factor that activates IL-11 receptors

Answer 7

1. Oprelkelvin
2. Eltombropag
3. Thrombopoietin
4. Romiplastim

Question 8

Drug that can be given to prevent secondary thrombocytopenia in patients undergoing cytotoxic chemotherapy for non-myeloid cancers

Answer 8

megakaryocyte growth factor

Question 9

____ small-molecule TPO receptor angonist; used to treat thrombocytopenia in adults and patients >/ 6 years old with ITP or splenectomy

Answer 9

Eltrombopag

Question 10

___ blocks binding of stromal cell-derived factor-1 alpha to the CXCR 4; mobilize progenitor and hematopoietic stemms cells from the bone marrow into peripheral blood; used for mobilization of hematopoietic stem cells

Answer 10

plerixafor

Question 11

___ fusion antibody-peptide that is a TPO receptor agonist;

stimulates proliferation and differentiation of monocytes, neutrophils, eosinophils, macrophages; used for thrombocytopenia

Answer 11

Romiplostim