Drugs on Smooth Muscles Flashcards
Amino acid precursor of histamine
histidine
[Histamine receptor]
Smooth muscle
H1, Gq, increase IP3/DAG
[Histamine receptor]
stomach
H2, Gs, increase cAMP
[Histamine receptor]
brain
H3, decrease cAMP
[Histamine receptor]
for leukocyte chemotaxis
H4, decrease cAMP
Antiemetic first generation antihistamine
promethazine
First generation antihistamine used in treating serotonin syndrome
Cyproheptadine
The dreaded side effect of first generation antihistamine
orsthostatic hypotension
A first generation antihistamine that has more antimotion sickness action than sedative action
Cyclizine
A first generation antihistamine with less antimotion sickness action, more sedative and autonomic effects
promethazine
generation of antihistamine that has no autonomic or antimotion sickness effect
Second generation H1 antagonist
Fatal arrhythmias can happen if the second generation antagonists, Terfenadine/Astemizole, are combined with this macrolide
Erythromycin
Fatal arrhythmias can happen if the second generation antagonists, Terfenadine/Astemizole, are combined with this antifungals
Azoles
Cite examples of H2 receptor antagonists
- Cimetidine
- Ranitidine
- Famotidine
- Nizatidine
H2 receptor antagonist that has antiandrogen effect
cimetidine
H2 receptor antagonist that has decreased hepatic flow
cimetidine