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Pharmacology > Drugs on Smooth Muscles > Flashcards

Drugs on Smooth Muscles Flashcards

1
Q

Amino acid precursor of histamine

A

histidine

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2
Q

[Histamine receptor]

Smooth muscle

A

H1, Gq, increase IP3/DAG

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3
Q

[Histamine receptor]

stomach

A

H2, Gs, increase cAMP

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4
Q

[Histamine receptor]

brain

A

H3, decrease cAMP

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5
Q

[Histamine receptor]

for leukocyte chemotaxis

A

H4, decrease cAMP

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6
Q

Antiemetic first generation antihistamine

A

promethazine

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7
Q

First generation antihistamine used in treating serotonin syndrome

A

Cyproheptadine

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8
Q

The dreaded side effect of first generation antihistamine

A

orsthostatic hypotension

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9
Q

A first generation antihistamine that has more antimotion sickness action than sedative action

A

Cyclizine

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10
Q

A first generation antihistamine with less antimotion sickness action, more sedative and autonomic effects

A

promethazine

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11
Q

generation of antihistamine that has no autonomic or antimotion sickness effect

A

Second generation H1 antagonist

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12
Q

Fatal arrhythmias can happen if the second generation antagonists, Terfenadine/Astemizole, are combined with this macrolide

A

Erythromycin

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13
Q

Fatal arrhythmias can happen if the second generation antagonists, Terfenadine/Astemizole, are combined with this antifungals

A

Azoles

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14
Q

Cite examples of H2 receptor antagonists

A
  1. Cimetidine
  2. Ranitidine
  3. Famotidine
  4. Nizatidine
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15
Q

H2 receptor antagonist that has antiandrogen effect

A

cimetidine

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16
Q

H2 receptor antagonist that has decreased hepatic flow

A

cimetidine

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17
Q

H2 receptor antagonis that is used in the ICU setting to prevent gastric erosion

A

ranitidine

18
Q

H2 receptor antagonist that is used to reduce nocturnal acid secretion and duodenal ulcer

A

Ranitidine

19
Q

Serotonin is derived from what amino acid?

A

tryptophan

20
Q

[Serotonin receptors]

Brain

A

5-HT 1D, Gi, decrease cAMP

21
Q

[Serotonin receptors]

smooth muscle

A

5HT2, Gq, increase IP3/DAG

22
Q

[Serotonin receptors]

platelets

A

5HT2, Gq, increase IP3/DAG

23
Q

[Serotonin receptors]

area postrema

A

5HT3, ligand gated

24
Q

[Serotonin receptors]

presynaptic terminal in the enteric nervous system

A

5-HT4, Gs, increase cAMP

25
Q

What is the DOC for acute migraine/cluster headache

A

-Triptans

5HT1D receptor agonists

26
Q

Drug used for postchemo/post operative vomiting

A

Ondansetron

5HT3 receptor antagonist

27
Q

5HT3 receptor antagonist used for Irritable bowel disease

28
Q

5HT3 receptor antagonist that has a SE of QRS and QT prolongation

A

Dolasetron

29
Q

5HT3 receptor antagonist that has a SE of constipation

30
Q

Responsible for the epidemics of St. Anthony’s fire

A

Ergot alkaloids

31
Q

Cite examples of vasoselective 5HT2 receptor antagonist

A
  1. Ergotamine
  2. Dihydroergotamine
  3. Methysergide
32
Q

Ergotamine is a partial agonist on what receptors?

A
  1. alpha

2. 5HT 2 receptors

33
Q

Ergotamine has a potent agonist effect on what receptors?

A

dopamine receptors

34
Q

5HT2 receptor antagonist that has a SE of retroperitoneal fibrosis?

A

methysergide

35
Q

histamine antagonist class that cause epinephrine reversal due to its partial agonist effect on alpha receptors

A

5HT2 receptor antagonist

36
Q

What is the antidote for ergotamine toxicity?

A

Nitroprusside

37
Q

Cite examples of uteroselective antihisaminse

A
  1. Ergonovine

2. Methylergonovine

38
Q

Drug of choice for post partum bleeding

A

Methylergonovine

39
Q

___ is a strong h3 receptor antagonist; used for balance disorders or to alleviate vertigo symptoms

A

Betahistine

40
Q

A drug that is both an antihistamine and CCB; used to treat cerebral apoplexy and post trauma cerebral symptoms and cerebral arteriosclerosis

A

cinnarazine

41
Q

A calcium entry blocker with calmudolin binding properties and H1 antagonistic activity; prophylaxis of migraine, occlusive peripheral vascular disease, vertigo and adjuvant for epilepsy

A

flunarazine

42
Q

Drug of choice for diabetic gastroparesis

A

Metoclopramide

Pharmacology (35 decks)

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