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Pharmacology > Opioid Antagonist > Flashcards

Opioid Antagonist Flashcards

1
Q

Opioid receptor responsible for inhibition of respiration

A

Mu

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2
Q

Opioid receptor responsible for development of tolerance

A

Delta

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3
Q

Opioid receptor responsible for slowing the GI transit

A

Kappa

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4
Q

[Opioid agonist: full]

SE: miosis

A

morphine

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5
Q

[Opioid agonist: full]

has a hemodynamic effect on the pulmonary ciculation

A

morphine

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6
Q

[Opioid agonist: full]

can be used as pain reliever in acute PI

A

morphine

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7
Q

[Opioid agonist: full]

given transdermal, for breakthrough cancer pain

A

fentanyl

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8
Q

[Opioid agonist: full]

causes hypertensive crisis when taken with tyramin

A

meperidine

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9
Q

[Opioid agonist: full]

used for spasmodic pain

A

meperidine

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10
Q

[Opioid agonist: full]

used to treat opioid dependence/withdrawal

A

methadone

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11
Q

What are examples of your partial opioid agonist

A

hydrocodone, dextromethorphan

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12
Q

[Opioid agonist: partial]

can caue hypogonadism, hearing loss

A

hydroxycodone

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13
Q

[Opioid agonist: partial]

decreases sensitivity of cough receptors

A

dextromethorphan

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14
Q

What are the side effects of morphine

A
  1. Miosis
  2. Restlessness
  3. Respiratory depression
  4. Postural hypotension
  5. Increase ICP
  6. Constipation
  7. urinary retention
  8. pruritus
  9. addiction liability
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15
Q

[Opioid agonist: weak]

examples of weak opioid agonist

A
  1. Propoxyphene
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16
Q

[Opioid agonist: weak

that can be used to treat restless leg syndrome

A

propoxyphene

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17
Q

[Opioid: mixed]

cite examples

A
  1. Nalbuphine
  2. Butorphanol
  3. Buprenorphine
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18
Q

[Opioid: mixed]

Can be used to reduce craving in alcohol dependence

A
  1. Nalbuphine
  2. Buprenorphine

resistant to naloxone reversal

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19
Q

[Opioid: antagonist]

MOA of naloxone

A

competitive inhibitor at mu, delta, kappa

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20
Q

[Opioid: antagonist]

used to treat opioid and alcohol dependence

A

naltrexone

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21
Q

[Opioid: dual acting]

MOA of tramadol

A

weak agonist at mu

22
Q

[Opioid: dual acting]

tramadol cannot be used in patient with history of

A

epilepsy

23
Q

[Opioid: dual acting]

can cause serotonin syndrome when used with SSRI

A

tramadol

24
Q

[General anesthesia: inhaled]

for dental procedures

A

Nitrous oxide

25
Q

[General anesthesia: inhaled]

causes megaloblastic anemia and bronchodilation

A

nitrous oxide

26
Q

[General anesthesia: inhaled]

lowest potency
highest MAC

A

nitrous oxide

27
Q

[General anesthesia: inhaled]

can cause bronchospasm

A

desflurane

28
Q

[General anesthesia: inhaled]

can cause renal insufficiency

A

sevoflurane, methoxyflurane

29
Q

[General anesthesia: inhaled]

can cause catecholamine induced arrythmias

A

Isoflurane

30
Q

[General anesthesia: inhaled]

has a spike and wave activity in EEG

A

Enflurane

31
Q

[General anesthesia: inhaled]

In used with succinylcholine can cause malignant hyperthermia

A

halothane

32
Q

[General anesthesia: IV]

increases duration of Cl channel

A

barbiturates

33
Q

[General anesthesia: IV]

can cause acute intermittent porphyria

A

barbiturates

34
Q

[General anesthesia: IV]

has rapid entry to the brain

A

barbiturates

35
Q

[General anesthesia: IV]

cause anterograde amnesia

A

Benzodiazepines

36
Q

Antidote of Midazolam

A

Flumazenil

37
Q

[General anesthesia: IV]

can cause dissociative amnesia

A

ketamine

38
Q

[General anesthesia: IV]

emergence delirium as post-op effect

A

ketamine

39
Q

to reduce emergence delirium due to ketamine, what will you give

A

benzodiazepine

40
Q

What happens when you give droperidol and NO?

A

Neuroleptanesthesia

41
Q

[General anesthesia: Miscellaneous]

can be used for patients with limited cardiorespiratory reserve

A

etomidate

42
Q

[General anesthesia: Miscellaneous]

cause post-op N/V

A

etomidate

43
Q

Milk of amnesia

A

propofol

44
Q

[General anesthesia: Miscellaneous]

Alpha 2 receptor agonist
decrease sympathetic tone
attenuates neuroendocrine with hemodynamic response to anesthesia and surgery

A

dexmetomidine

45
Q

Most allergenic among all local anesthetics?

A

tetracaine

46
Q

only local anesthesia that vasoconstricts

A

cocaine

47
Q

Antiarrhythmic local anesthesia used post-MI

A

Lidocaine

48
Q

To decrease systemic absorption of lidocaine, this can be given

A

epinephrine

49
Q

Local anesthesia used in dental procedures

A

prilocaine

50
Q

Local anesthesia which can cause methemoglobinemia

A

prilocaine

51
Q

what drug will you give to counter methemoglobinemia

A

methylene blue

52
Q

Bupivacaine cardiotoxicity can be treated with

A

Intralipid/Liposomal forms

Pharmacology (35 decks)

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