Heart Failure Drugs

Question 1

[Therapeutic Strategies of CHF]

removal of salt and water

Answer 1

diuretics

Question 2

[Therapeutic Strategies of CHF]

reduction of afterload and salt and water retention

Answer 2

ACEi

Question 3

[Therapeutic Strategies of CHF]

reduction of excessive sympathetic stimulation by means of

Answer 3

beta blockers

Question 4

[Therapeutic Strategies of CHF]

direct augmentation of depressed cardiac contractility

Answer 4

positive inotropes

Question 5

What is the MOA of digoxin

Answer 5

inhibits NaK ATPase resulting to increased intracellular Ca

Question 6

Administration of digoxin leads to reduction of the clearance of the following drugs

Answer 6

Quinidine
Amiodarone
Cyclosporine
Diltiazem
Verapamil

VCQAD

VIKAD

Question 7

Electrolyte imbalances that can predispose a patient taking digoxin to arrythmogenesis

Answer 7

Hypokalemia
Hypomagnesemia
Hypercalcemia

Question 8

what is the most common ECG change in digoxin toxity?

Answer 8

PVC

Question 9

What drugs gave narrow therapeutic index?

Answer 9

Warfarin
Aminoglycosides
Lithium
Amphotericin B
Carbamazepine
Phenobarbital
Phenytoin
Vancomycin
Theophylline
Digoxin

Question 10

Drug of choice in treating digitalis toxciity?

Answer 10

lidocaine

Question 11

If digoxin antibodies are not available in treating digitalis toxicity, ince can give?

Answer 11

bile acid binding resin

Question 12

what is the first line therapy for both systolic and diastolic failure?

Answer 12

diuretics

Question 13

What is the drug of choice for immediate reduction of pulmonary congestion and severe edema associated with heart failure?

Answer 13

furosemide

Question 14

diuretics with significant long-term benefit, can reduce mortality in chronic failure

Answer 14

spironolactone, eplerenone

Question 15

Beta 1 selective sympathomimetics that are useful in acute heart failure

Answer 15

dobutamine

dopamine

Question 16

____ increase cAMP by inhibiting its breakdown by; increase intracellular Ca2 then vasodilation;

cant be used in chronic HF because they increase morbidity and mortality

Answer 16

phosphodiesterase inhibitor

Question 17

vasodilator that can be used for acute severe HF with congestion

Answer 17

nitroprusside

nitroglycerin

Question 18

___ is a BNP analog, increases cGMP

used for acute decompensated failur

Answer 18

Nesiritide

Question 19

what drugs have been shown to improve survival in cases of HF?

Answer 19

1. ACEi
2. BB
3. Aldosterone antagonist

Question 20

___ is an antihypertensive drug used in combination with valsartan

prodrug which is sacubitrilat

Answer 20

sacubitril

Question 21

sacubitrilat inhibits the enzyme that is responsible for the degradation of atrial and BNP

Answer 21

neprilysin

used in HFrEF

Question 22

Agonist of natriuretic peptide receptors resulting to increased sodium and water excretion

Answer 22

Nesritide

Carperitide

Question 23

Drug that decreases metabolism of natriuretic peptides and decreases formation of angiotensin II

Answer 23

Omapatrilat

Question 24

Drug used for pulmonary hypertension; act as a nonselective antagonist of endothelin ETa and ETb receptors

Answer 24

1. Bosentan

2. Macitentan

Question 25

What is the prodrug of aprepitant

Answer 25

Fosaprepitant

Question 26

Drug that is a selective antagonist of tachykinin NK1 receptor blocking effects of substance P

used in prevention of chemotherapy induced N/V

Answer 26

Aprepitant