Heart Failure Drugs Flashcards
[Therapeutic Strategies of CHF]
removal of salt and water
diuretics
[Therapeutic Strategies of CHF]
reduction of afterload and salt and water retention
ACEi
[Therapeutic Strategies of CHF]
reduction of excessive sympathetic stimulation by means of
beta blockers
[Therapeutic Strategies of CHF]
direct augmentation of depressed cardiac contractility
positive inotropes
What is the MOA of digoxin
inhibits NaK ATPase resulting to increased intracellular Ca
Administration of digoxin leads to reduction of the clearance of the following drugs
Quinidine Amiodarone Cyclosporine Diltiazem Verapamil
VCQAD
VIKAD
Electrolyte imbalances that can predispose a patient taking digoxin to arrythmogenesis
Hypokalemia
Hypomagnesemia
Hypercalcemia
what is the most common ECG change in digoxin toxity?
PVC
What drugs gave narrow therapeutic index?
Warfarin Aminoglycosides Lithium Amphotericin B Carbamazepine Phenobarbital Phenytoin Vancomycin Theophylline Digoxin
Drug of choice in treating digitalis toxciity?
lidocaine
If digoxin antibodies are not available in treating digitalis toxicity, ince can give?
bile acid binding resin
what is the first line therapy for both systolic and diastolic failure?
diuretics
What is the drug of choice for immediate reduction of pulmonary congestion and severe edema associated with heart failure?
furosemide
diuretics with significant long-term benefit, can reduce mortality in chronic failure
spironolactone, eplerenone
Beta 1 selective sympathomimetics that are useful in acute heart failure
dobutamine
dopamine
____ increase cAMP by inhibiting its breakdown by; increase intracellular Ca2 then vasodilation;
cant be used in chronic HF because they increase morbidity and mortality
phosphodiesterase inhibitor
vasodilator that can be used for acute severe HF with congestion
nitroprusside
nitroglycerin
___ is a BNP analog, increases cGMP
used for acute decompensated failur
Nesiritide
what drugs have been shown to improve survival in cases of HF?
- ACEi
- BB
- Aldosterone antagonist
___ is an antihypertensive drug used in combination with valsartan
prodrug which is sacubitrilat
sacubitril
sacubitrilat inhibits the enzyme that is responsible for the degradation of atrial and BNP
neprilysin
used in HFrEF
Agonist of natriuretic peptide receptors resulting to increased sodium and water excretion
Nesritide
Carperitide
Drug that decreases metabolism of natriuretic peptides and decreases formation of angiotensin II
Omapatrilat
Drug used for pulmonary hypertension; act as a nonselective antagonist of endothelin ETa and ETb receptors
- Bosentan
2. Macitentan
What is the prodrug of aprepitant
Fosaprepitant
Drug that is a selective antagonist of tachykinin NK1 receptor blocking effects of substance P
used in prevention of chemotherapy induced N/V
Aprepitant
