Adrenoceptor Blockers Flashcards

1
Q

[non-selective alpha blockers]

drug of choice for pheochromocytoms (pre-surgical)

A

phenoxybenzamine

also blocks H1, Ach, and serotonin

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2
Q

[non-selective alpha blockers]

irreversibly block alpha adrenergic receptors (alpha 1 > alpha 2) by forming a covalent bond with the receptors

A

phenoxybenzamine

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3
Q

[alpha non-selective]

antidote to alpha 1 agonist overdose

A

phentolamine

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4
Q

[alpha non-selective]

antidote of rebound hypertension

A

phentolamine, tolazoline

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5
Q

[alpha non-selective]

reverses the effects of local anesthetics in soft tissue sites

A

phentolamine

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6
Q

[selective alpha-1 blockers]

used for BPH

A

tamsulosin

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7
Q

[selective alpha-1 blockers]

SE: increased HDL

A

prazosin

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8
Q

[selective alpha-1 blockers]

may precipitate intraoperative floppy iris syndrome in patients undergoing cataract surgery

A

tamsulosin

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9
Q

[diagnose]

flaccid iris, propensity for iris to collapse, progressive intraoperative pupillary constriction in patients taking tamsulosin during a cataract surgery

A

Intraoperative floppy iris syndrome

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10
Q

[selective alpha-1 blockers]

drugs that are not used for females or for the treatment of hypertension

A
  1. Doxazosin
  2. Tamsulosin
  3. Silodosin
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11
Q

Reflex tachycardia is less common and less severe in this drug class

A

alpha 1 selectivity

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12
Q

[selective alpha 2 blocker]

used to treat male erectile dysfunction

A

yohimbine

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13
Q

[selective alpha 2 blocker]

yohimbine can greatly elevate BP if administered to patients taking what drug

A

NE-transport blocking drug

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14
Q

[nonselective beta blocker]

drug of choice for performance anxiety

A

propanolol

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15
Q

[nonselective beta blocker]

can be given to glaucoma

A

propanolol

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16
Q

[nonselective beta blocker]

combination of this beta blockers can be used to treat pheochromocytoma

A

carvedilol and labetalol

17
Q

this masks the symptoms of hypoglycemia in diabetics

A

non-selective beta blocker

18
Q

[nonselective beta blocker]

this drug has a marked class III antiarrythmic effect

A

sotalol

19
Q

[nonselective beta blocker]

blocks the effect of thyroid storm by inhibiting peripheral conversion of thyroxine to T3

A

propanolol

20
Q

a patient taking a topical beta blocker with oral verapamil can experience

A
  1. severe hypotension
  2. bradycardia
  3. Heart failure
  4. cardiac conduction abnormalities
21
Q

what is the main contraindication to beta antagonist use?

A
  1. Preexisting AV block

2. cardiac failure not caused by tachycardia

22
Q

these beta blockers prolong the survival in patients with MI

A
  1. Propanolol
  2. Metoprolol
  3. TImolol
23
Q

these beta blockers reduce the mortality in selected patients with chronic heart failure

A
  1. Bisoprolol
  2. Metoprolol
  3. Carvedilol
24
Q

beta blockers that are less likely to cayse bronchospasm

A
  1. Acebutolol
  2. Pindolol
  3. Labetolol
25
Q

What are the disadvantages when betablocker are used topically in the eye

A
  1. Decreases protective reflexes

2. Increases risk of corneal ulceration

26
Q

These betablockers have no local anesthetic effect; useful in glaucoma

A

timolol

betaxolol

27
Q

Betablockers with both alpha and beta antagonist property

A
  1. Carvedilol
  2. Labetalol
  3. Nebivolol
28
Q

[Selective beta 1 blockers]

drug that can lead to tachycardia

A

esmolol

29
Q

[Selective beta 1 blockers]

principan contracindication are

A
  1. Preexisting AV block

2. cardiac failure not caused by tachycardia

30
Q

[Selective beta 1 blockers]

shown to lower birthweights and impair fetal growth

A

atenolol

31
Q

What is the antidote for beta 1 blocker induced AV nodal blockade?

A

glucagon