Adrenoceptor Blockers Flashcards
[non-selective alpha blockers]
drug of choice for pheochromocytoms (pre-surgical)
phenoxybenzamine
also blocks H1, Ach, and serotonin
[non-selective alpha blockers]
irreversibly block alpha adrenergic receptors (alpha 1 > alpha 2) by forming a covalent bond with the receptors
phenoxybenzamine
[alpha non-selective]
antidote to alpha 1 agonist overdose
phentolamine
[alpha non-selective]
antidote of rebound hypertension
phentolamine, tolazoline
[alpha non-selective]
reverses the effects of local anesthetics in soft tissue sites
phentolamine
[selective alpha-1 blockers]
used for BPH
tamsulosin
[selective alpha-1 blockers]
SE: increased HDL
prazosin
[selective alpha-1 blockers]
may precipitate intraoperative floppy iris syndrome in patients undergoing cataract surgery
tamsulosin
[diagnose]
flaccid iris, propensity for iris to collapse, progressive intraoperative pupillary constriction in patients taking tamsulosin during a cataract surgery
Intraoperative floppy iris syndrome
[selective alpha-1 blockers]
drugs that are not used for females or for the treatment of hypertension
- Doxazosin
- Tamsulosin
- Silodosin
Reflex tachycardia is less common and less severe in this drug class
alpha 1 selectivity
[selective alpha 2 blocker]
used to treat male erectile dysfunction
yohimbine
[selective alpha 2 blocker]
yohimbine can greatly elevate BP if administered to patients taking what drug
NE-transport blocking drug
[nonselective beta blocker]
drug of choice for performance anxiety
propanolol
[nonselective beta blocker]
can be given to glaucoma
propanolol
[nonselective beta blocker]
combination of this beta blockers can be used to treat pheochromocytoma
carvedilol and labetalol
this masks the symptoms of hypoglycemia in diabetics
non-selective beta blocker
[nonselective beta blocker]
this drug has a marked class III antiarrythmic effect
sotalol
[nonselective beta blocker]
blocks the effect of thyroid storm by inhibiting peripheral conversion of thyroxine to T3
propanolol
a patient taking a topical beta blocker with oral verapamil can experience
- severe hypotension
- bradycardia
- Heart failure
- cardiac conduction abnormalities
what is the main contraindication to beta antagonist use?
- Preexisting AV block
2. cardiac failure not caused by tachycardia
these beta blockers prolong the survival in patients with MI
- Propanolol
- Metoprolol
- TImolol
these beta blockers reduce the mortality in selected patients with chronic heart failure
- Bisoprolol
- Metoprolol
- Carvedilol
beta blockers that are less likely to cayse bronchospasm
- Acebutolol
- Pindolol
- Labetolol
What are the disadvantages when betablocker are used topically in the eye
- Decreases protective reflexes
2. Increases risk of corneal ulceration
These betablockers have no local anesthetic effect; useful in glaucoma
timolol
betaxolol
Betablockers with both alpha and beta antagonist property
- Carvedilol
- Labetalol
- Nebivolol
[Selective beta 1 blockers]
drug that can lead to tachycardia
esmolol
[Selective beta 1 blockers]
principan contracindication are
- Preexisting AV block
2. cardiac failure not caused by tachycardia
[Selective beta 1 blockers]
shown to lower birthweights and impair fetal growth
atenolol
What is the antidote for beta 1 blocker induced AV nodal blockade?
glucagon
