Miscellaneous GI drug

Question 1

decreases cholesterol content of bile by reducing cholesterol secretion; stabilize hepatocyte canalicular membranes

Answer 1

Ursodiol (Ursodeoxycholic acid)

Question 2

amino acid derivative of quinolinone; for mucosal protection of healing gastroduodenal ulcers; treatment of gastritis by enhancing mucosal defense

Answer 2

Rebamipide

Question 3

prokinetic benzamide derivative; inhibit dopamine and acetylcholine esterase enzyme; has gastrokinetic effect; used for functional dyspepsia and gastroparesis

Answer 3

itopride

Question 4

changes surface tension of gas bubbles; causes collapse of foam bubbles preventing gas pockets in GIT

Answer 4

simethicone

Question 5

a gastroprokinetic agent that acts as selective 5HT4 agonist; its major metabolite acts additionally in 5HT3 antagonis;

used for the treatment of gastritis, GERD, functional dyspepsia, IBS

Answer 5

mosapride

Question 6

5HT4 agonist

used for chronic constipation and intestinal pseudoobstruction

Answer 6

prucalopride

Question 7

antimuscarinic and CCB ; used to relieve spasmodic pain of the gust especially in IBS

Answer 7

Otilonium bromide

Question 8

Antispasmodic; increases the intracellular level of cAMP in the smooth muscular cell and binding of Ca ions into the sarcoplasmic reticulum

Answer 8

Tiropramide

Question 9

increases the availability of endogenous opioids (enkephalins), inhibits membrane bound enkephalinase

Answer 9

racecadotril

Question 10

probiotic; has antimicrobial substances that are active against G+ bacteria

Answer 10

bacillus clausii

Question 11

broad spectrum intestinal infectious agent used for acute diarrhea

Answer 11

nifuroxazide

Question 12

hepatoprotectant; anti-inflammatory and anticarcinogenic; neutralize the hepatotoxicity of amanita phalloides, ethanol, paracetamol. CCl4

Answer 12

silymarin

Question 13

increases biliary secretion, relieves spasm of the bile ducts, enhances metabolic liver function and reduces biliary stasis; can inhibit HMG-CoA reductase enzyme

Answer 13

Rowachol

Question 14

[anorectal preparaion]

venotropic drug; used for venous insufficiency; increase venous tone, improves lymph drainage, protects microcirculation; reduces precapillary permeability

Answer 14

daflon

Diospin + Hesperidin

Question 15

arrests bleeding by coagulating blood protein and including muscle fiber of small blood vessels to contract; has antimicrobial effect

Answer 15

Policresulen + Cinchocaine