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Pharmacology > Anti-Parkinsonism, Psychotics, Depressants > Flashcards

Anti-Parkinsonism, Psychotics, Depressants Flashcards

1
Q

[Antiparkinsonism]

Type of dopa precursor that inhibits deopa decarboxylase

A

Carbidopa

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2
Q

[Antiparkinsonism]

what drug is given to prolong the DOA of Levodopa-Carbidopa

A

COMT

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3
Q

[Antiparkinsonism]

combination of levodopa ang MAOIs can cause ___ crisis

A

hypertensive crisis

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4
Q

[Antiparkinsonism]

what is the drug of choice for parkinsons disease

A

Levodopa-Carbidopa

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5
Q

[Antiparkinsonism]

What drug can result to inhibition of prolactin release?

A
  1. Bromocriptine
  2. Cabergoline
  3. Pergolide
  4. Piribedil
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6
Q

[Antiparkinsonism]

can also be used in levodopa intolerance and intermittent claudication

A
  1. Bromocriptine
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7
Q

[Antiparkinsonism]

An ergot agonist that can act as D3 agonist and alpha 2 adrenergic antagonis

A

Bromocriptine

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8
Q

[Antiparkinsonism]

A non-ergot agonist that is used in restless leg syndrome

A

Pramipexole

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9
Q

[Antiparkinsonism]

drug that has a side effect of compulsive gambling, hypersexuality

A

Pramipexole (Ropinirole)

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10
Q

[Antiparkinsonism]

partial D3 receptor agonist
antagonist at 5HT3
antagonist alpha adrenergic

A

Apomorphine

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11
Q

[Antiparkinsonism]

drug used to treat opiate addiction and erectile dysfunction

A

apomorphine

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12
Q

[Antiparkinsonism]

apomorphine is combined with this drug to prevent severe nausea

A

Trimethobenzamide

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13
Q

[Antiparkinsonism]

This inhibits COMT in the periphery prolonging L-dopa response

A
  1. Entacapone

2. Tolcapone

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14
Q

[Antiparkinsonism]

can also cause orange urine as SE

A

Entacapone

Tolcapone

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15
Q

[Antiparkinsonism]

Tolcapone is a COMT inhibitor at ___

A

CNS and periphery

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16
Q

[Antiparkinsonism]

used as adjunct to antisychotics and adjunct treatment for PES caused by antipsychotics

A
  1. Benztropine
  2. Procyclidine
  3. Trihexyphenidyl
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17
Q

[Antiparkinsonism]

anticholinergics given to patients with parkinsons can lead to exacerbation of

A

tardive dyskinesia

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18
Q

[Antiparkinsonism]

anticholinergics can also ne given to patients with parkinsons since it improves ___

A

tremor and rigidity

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19
Q

[Antiparkinsonism]

an anti influenza drug that can be given to patients with parkinson since it potentiates dopaminergic function

A

amantadine

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20
Q

[Antiparkinsonism]

used once a day as transdermal patch, this dopamine antagonist is used to treat restless leg syndrome

A

Rotigotine

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21
Q

[Antiparkinsonism]

can cause livedo reticularis

A
  1. Amantadine
  2. Hydroxyurea
  3. Minocycline
  4. Gemtacibine
  5. Quinidine
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22
Q

[Huntington’s Disease]

What are the drugs can you give for huntington’s disease

A
  1. Tetrabenzamine

2. Reserpine

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23
Q

What are you dopamine derivatives?

A
  1. NE
  2. Adrenaline
  3. DOPAC
  4. HVA
  5. Methoxytyramine
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24
Q

[Antipsychotics: typical]

can cause corneal and lens deposits

A
  1. Chlorpromazine
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25
Q

[Antipsychotics: typical]

Can cause retinal deposits

A

Fluphenazine

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26
Q

[Antipsychotics: typical]

Only antipsychotic with fata overdose

A

Fluphenazine

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27
Q

[Antipsychotics: typical]

causes the most EPS

A

haloperidol

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28
Q

[Antipsychotics: typical]

can cause hyperprolactinemia

A
  1. Fluphenazine

2. Chlorpromazine

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29
Q

[Antipsychotics: atypical]

Reduces suicide risk

A

Clozapine

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30
Q

[Antipsychotics: atypical]

causes agranulocytosis

A

[Antipsychotics: atypical]

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31
Q

[Antipsychotics: atypical]

can be used in pregnancy,

A
  1. Quetiapine

2. Olanzapine

32
Q

[Antipsychotics: atypical]

increases mortality in elderly with dementia related psychosis

A

Ziprazidone

33
Q

[Antipsychotics: atypical]

used for anorexia

A

Olanzapine

34
Q

[Antipsychotics: atypical]

the only antipsychotic used for the youth and elderly

A

Risperidone

35
Q

[Antipsychotics: atypical]

used to treat intractable hiccups

A

Risperidone

36
Q

[Antipsychotics: atypical]

least sedating among all atypicals

A

aripiprazole

37
Q

[Antipsychotics: atypical]

used to treat cocaine dependence

A

aripiprazole

38
Q

What is the MOA of lithium

A

decreases cAMP

39
Q

What disease is contraindicated with intake of lithium

A

sick sinus syndrome

40
Q

[Antidepressants]

What is the MOA of your tricyclic antidepressants?

A

Blocks the NE and 5HT transporters

41
Q

[Antidepressants: tricyclic antidepressants]

Can be used to treat OCD

A

Clomipramine

42
Q

[Antidepressants: tricyclic antidepressants]

What are the signs of overdose

A

Coma
Convulsions
Cardiotoxicity

43
Q

[Antidepressants: tricyclic antidepressants]

Imipramine is metabolized to what ____

A

Despiramine

44
Q

[Antidepressants: tricyclic antidepressants]

Amitriptyline is metabolized to

A

Nortryptylin

45
Q

What is the MOA of SSRI

A

Inhibit neuronal reuptake of serotonin transporter

46
Q

[Antidepressants: SSRI]

DOC for OCD

A

Fluoxetine

47
Q

[Antidepressants: SSRI]

First line drug for MDD

A

Escitalopram

Sertaline

48
Q

[Antidepressants: SSRI]

Can cause QT prolongation

A

Citalopram

49
Q

[Antidepressants: SSRI]

What are examples of you SSRIs

A
  1. Fluoxetine
  2. Paroxetine
  3. Citalopram
  4. Escitalopram
  5. Sertraline
  6. Fluvoxamine
  7. Vilazodone
50
Q

[Antidepressants: SNRI]

What is the MOA of your SNRI?

A

inhibit neuronal reuptake of serotonin and NE by binding to both transporter

51
Q

[Antidepressants: SNRI]

Can be used to treat DM neuropathy

A
  1. Venlafaxine
52
Q

[Antidepressants: SNRI]

Cite examples of SNRI

A
  1. Venlafaxine
  2. Duloxetine
  3. Desvenlafaxine
  4. Milnacipran
53
Q

[Antidepressants: SNRI]

SE : Hypertension and CNS stimulation

A

Venlafaxine

54
Q

[Antidepressants: SNRI]

more selective for NE reuptake

A

Milnacipram

55
Q

[Antidepressants: SNRI]

Less affinity for NE transporters

A

Venlafaxine

56
Q

[Antidepressants: Tetracyclic]

Lowers seizure threshold

57
Q

[Antidepressants: Tetracyclic]

SE: amenorrhea-galactorrhea syndrome

58
Q

[Antidepressants: Tetracyclic]

increases amine release from nerve endings by antagonism of presynaptic alpha 2 adrenoceptors

A

Mirtazapine

59
Q

[Antidepressants: Tetracyclic]

appetite stimulation

A

Mirtazapine

60
Q

[Antidepressants: Tetracyclic]

used to treat alcohol depression

A

Buproprion

61
Q

[Antidepressants: Tetracyclic]

used for smoking cessation

62
Q

[Antidepressants: Serotonin Antagonist]

Cite examples of your serotonin antagonists

A
  1. Trazodone
  2. Nefazodone
  3. Vortioxetine
63
Q

[Antidepressants: Serotonin Antagonist]

Used for hypnosis/ sleeping aid

64
Q

[Antidepressants: Serotonin Antagonist]

blocks 5HT2 receptors

65
Q

[Antidepressants: Serotonin Antagonist]

blocks SERT

A

Nefazodone

66
Q

[Antidepressants: Serotonin Antagonist]

cause priapism

67
Q

[Antidepressants: MAOI]

Intake with ___ alongside a MAOI can cause hypertensive crisis

68
Q

[Antidepressants: MAOI]

Serotonin syndrome can be due to a MAO + ____

69
Q

[Antidepressants: MAOI]

MAO-B selective

70
Q

[Antidepressants: MAOI]

non-selective MAO

A

Tranycyclopramine

71
Q

[Diagnose]

Fever
Acidosis
Rhabdomyolysis
Trismus
Clonus
Hypertension
A

malignant hyperthermia

FART CH

72
Q

[Diagnose]

Fever
Agitation
Tremor
Clonus
Hyperreflexia
Diaphoresis
A

Serotonin Syndrome

FAT CHiLD

73
Q

[Diagnose]

Fever
Encephalopathy
Vitals unstable
Elevated CPK
Rigidity
A

Neuroleptic Malignant syndrome

FEVER

74
Q

What are the drugs you can use to treat Neuroleptic Malignant Syndrome

A
  1. Dantrolene
  2. Bromocriptine
  3. Amantadine
  4. Diazepam
75
Q

Drugs that cause Priapism

A
  1. Trazodone
  2. Papaverine
  3. Sildenafil
  4. Quetiapine
  5. Alprostadil
  6. Warfarin
  7. Bupoprion
76
Q

Drugs that cause erectile dysfunction

A
  1. SSRI
  2. Opiates
  3. Risperidone
  4. Ethanol
  5. Estrogen
  6. Spironolactone
  7. Propranolol
  8. Finasteride
  9. Hydrochlorothiazide

Pharmacology (35 decks)

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