Dyslipidemia Flashcards
Hyperlipiproteinemia associated with high incidence of acute pancreatitis
hyperchylomicronemia
[Statins]
what is the MOA of statins
inhibit hepatic cholesterol synthesis by inhibiting HMG-COA
Which drug causes the modest reduction in triglycerides?
statins
[Statins]
Which of the following are prodrugs?
simvastatin and lovastatin
[Statins]
Greater maximal effect than other statins
Rosuvastatin
Atorvastatin
Simvastatin
resins are given at least how many hours after taking statins?
1 hour
if resin was taken first, how many hours after will you give your statins?
4 hours after
why are statins used in the management of CAD?
for plaque stabilization
Bile acid resins lead to compensatory increase in ____
increase in high-affinity LDL receptors and increases LDL removal
What are examples of bile acid resins?
- Cholestyramine
- Colestipol
- Colesevelam
bile acid resins can also be given to ____ toxicity
digitalis
drug of choice for pruritus in cholestasis
cholestyramine
what is the MOA of cholesterol absorption blockers?
inhibits NPC1L1 transporter
What drug prevents the absorption of dietary cholesterol and cholesterol that is excreted in bile?
ezetimibe
preferred drug for high LDL
ezetimibe
a sterol absorption blocker that is a cholesterol analog that decreases intestinal absorption of cholesterol and other phytosterols
sitosterol
sterol absorption blocker that can cause impotence (rare)
sitosterol
niacin inhibits lipolysis by acting on what enzyme?
hormone sensitive lipase
what is the most effective agent in increasing HDL level?
niacin
____ decreases catabilism of ApoA-I.
niacin
prominent side effects of this drug is flushing, pruritus, and rashes
niacin
Pretreat with aspirin to reduce flushing
what are the drugs that can cause flushing?
Vancomycin
Adenosine
Niacine
CCBs
___ are ligands for the peroxisome proliferator-activated receptor-alpha protein in which this drug will act to increase clearance of triglyceride
fibrate
The DOC for hypertriglyceridemia
Gemfibrozil
im combined with statin, gemfibrozil can increase the risk for?
myopathy and rhabdomyolysis
[Know the DOC]
I. Primary hyperchylomicronemia
low fat diet
[Know the DOC]
II. Familial hypercholesterolemia
statin
[Know the DOC]
III. Familial combined hypercholesterolemia
statin
[Know the DOC]
II. Familial dysbetalipoproteinemia
fibrate, niacin
[Know the DOC]
IV. Familial hypertriglyceridemia
fibrate, niacin
[Know the DOC]
V. Familial combined hypertriglyceridemia
fibrate, niacin
[synergistic antihyperlipidemic cimbination]
Niacin + statin
Familial hypercholesterolemia
[synergistic antihyperlipidemic cimbination]
statin + ezetimibe
familial hypercholesterolemia
[synergistic antihyperlipidemic cimbination]
Niacin + resin
familial combined hypercholesterolemia
[synergistic antihyperlipidemic cimbination]
statin + fibrate
familial combined hypercholesterolemia
[disadvantageous combination]
fibrate + resin
increased risk of cholelithiasis
[disadvantageous combination]
statin + resin
impaired statin absorption
[disadvantageous combination]
statin + fibrate
increased risk of myopathy and rhabdomyolysis
___ is an antioxidant that can inhibit the oxidation of LDL and lowers the level of cholesterol in the blood stream, inhibit early stages of cholesterol biosynthesis
probucol
[disadvantageous combination]
fibrate + resin
increased risk of cholelithiasis
[disadvantageous combination]
statin + resin
impaired statin absorption
[disadvantageous combination]
statin + fibrate
increased risk of myopathy and rhabdomyolysis
___ is an antioxidant that can inhibit the oxidation of LDL and lowers the level of cholesterol in the blood stream, inhibit early stages of cholesterol biosynthesis
probucol
myalgia among patients taking Statins is due to?
blockage of farnesyl pyrophosphate can also affect NaK ATPase. This leads to cell swelling presenting as myalgia
Niacin-induced flushing can be treated with
Niacin 200mg
Aspirin
Bile acid resin is absorbed in what part of GIT?
terminal ileum
____ lipid lowering drug that can also cause cholelithiasis?
fenofibrate
