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Pharmacology > Dyslipidemia > Flashcards

Dyslipidemia Flashcards

1
Q

Hyperlipiproteinemia associated with high incidence of acute pancreatitis

A

hyperchylomicronemia

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2
Q

[Statins]

what is the MOA of statins

A

inhibit hepatic cholesterol synthesis by inhibiting HMG-COA

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3
Q

Which drug causes the modest reduction in triglycerides?

A

statins

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4
Q

[Statins]

Which of the following are prodrugs?

A

simvastatin and lovastatin

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5
Q

[Statins]

Greater maximal effect than other statins

A

Rosuvastatin
Atorvastatin
Simvastatin

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6
Q

resins are given at least how many hours after taking statins?

A

1 hour

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7
Q

if resin was taken first, how many hours after will you give your statins?

A

4 hours after

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8
Q

why are statins used in the management of CAD?

A

for plaque stabilization

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9
Q

Bile acid resins lead to compensatory increase in ____

A

increase in high-affinity LDL receptors and increases LDL removal

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10
Q

What are examples of bile acid resins?

A
  1. Cholestyramine
  2. Colestipol
  3. Colesevelam
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11
Q

bile acid resins can also be given to ____ toxicity

A

digitalis

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12
Q

drug of choice for pruritus in cholestasis

A

cholestyramine

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13
Q

what is the MOA of cholesterol absorption blockers?

A

inhibits NPC1L1 transporter

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14
Q

What drug prevents the absorption of dietary cholesterol and cholesterol that is excreted in bile?

A

ezetimibe

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15
Q

preferred drug for high LDL

A

ezetimibe

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16
Q

a sterol absorption blocker that is a cholesterol analog that decreases intestinal absorption of cholesterol and other phytosterols

A

sitosterol

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17
Q

sterol absorption blocker that can cause impotence (rare)

A

sitosterol

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18
Q

niacin inhibits lipolysis by acting on what enzyme?

A

hormone sensitive lipase

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19
Q

what is the most effective agent in increasing HDL level?

A

niacin

20
Q

____ decreases catabilism of ApoA-I.

A

niacin

21
Q

prominent side effects of this drug is flushing, pruritus, and rashes

A

niacin

Pretreat with aspirin to reduce flushing

22
Q

what are the drugs that can cause flushing?

A

Vancomycin
Adenosine
Niacine
CCBs

23
Q

___ are ligands for the peroxisome proliferator-activated receptor-alpha protein in which this drug will act to increase clearance of triglyceride

A

fibrate

24
Q

The DOC for hypertriglyceridemia

A

Gemfibrozil

25
Q

im combined with statin, gemfibrozil can increase the risk for?

A

myopathy and rhabdomyolysis

26
Q

[Know the DOC]

I. Primary hyperchylomicronemia

A

low fat diet

27
Q

[Know the DOC]

II. Familial hypercholesterolemia

A

statin

28
Q

[Know the DOC]

III. Familial combined hypercholesterolemia

A

statin

29
Q

[Know the DOC]

II. Familial dysbetalipoproteinemia

A

fibrate, niacin

30
Q

[Know the DOC]

IV. Familial hypertriglyceridemia

A

fibrate, niacin

31
Q

[Know the DOC]

V. Familial combined hypertriglyceridemia

A

fibrate, niacin

32
Q

[synergistic antihyperlipidemic cimbination]

Niacin + statin

A

Familial hypercholesterolemia

33
Q

[synergistic antihyperlipidemic cimbination]

statin + ezetimibe

A

familial hypercholesterolemia

34
Q

[synergistic antihyperlipidemic cimbination]

Niacin + resin

A

familial combined hypercholesterolemia

35
Q

[synergistic antihyperlipidemic cimbination]

statin + fibrate

A

familial combined hypercholesterolemia

36
Q

[disadvantageous combination]

fibrate + resin

A

increased risk of cholelithiasis

37
Q

[disadvantageous combination]

statin + resin

A

impaired statin absorption

38
Q

[disadvantageous combination]

statin + fibrate

A

increased risk of myopathy and rhabdomyolysis

39
Q

___ is an antioxidant that can inhibit the oxidation of LDL and lowers the level of cholesterol in the blood stream, inhibit early stages of cholesterol biosynthesis

A

probucol

40
Q

[disadvantageous combination]

fibrate + resin

A

increased risk of cholelithiasis

41
Q

[disadvantageous combination]

statin + resin

A

impaired statin absorption

42
Q

[disadvantageous combination]

statin + fibrate

A

increased risk of myopathy and rhabdomyolysis

43
Q

___ is an antioxidant that can inhibit the oxidation of LDL and lowers the level of cholesterol in the blood stream, inhibit early stages of cholesterol biosynthesis

A

probucol

44
Q

myalgia among patients taking Statins is due to?

A

blockage of farnesyl pyrophosphate can also affect NaK ATPase. This leads to cell swelling presenting as myalgia

45
Q

Niacin-induced flushing can be treated with

A

Niacin 200mg

Aspirin

46
Q

Bile acid resin is absorbed in what part of GIT?

A

terminal ileum

47
Q

____ lipid lowering drug that can also cause cholelithiasis?

A

fenofibrate

Pharmacology (35 decks)

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