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Pharmacology > Gastointestinal Drugs > Flashcards

Gastointestinal Drugs Flashcards

1
Q

[Antacid]

Causes belching, metabolic alkalosis, fluid retention

A

sodium bicarbonate

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2
Q

[Antacid]

causes hypercalcemia, renal insufficiency, metabolic alkalosis (milk alkali syndrome)

A

Calcium carbonate

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3
Q

Antacids impairs absorption of these compounds thus it should not be given within 2 hours with this drug

A
  1. Fluoroquinolones
  2. Itraconazole
  3. Iron
  4. Tetracycline
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4
Q

[Maalox]

Between magnesium and aluminum, which causes diarrhea?

A

magnesium

Magtatae ka

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5
Q

[Maalox]

Between magnesium and aluminum, which causes constipation?

A

Aluminum

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6
Q

H2 receptor antagonist that can cause gynecomastia

A

Cimetidine

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7
Q

H2 receptor antagonist that is highly effective in suppressing nocturnal acid secretion

A

Cimetidine

can be used for pregnant patients

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8
Q

What is the drug of choice for PUD?

A

PPI

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9
Q

What is the MA of omeprazole?

A

inhibit HK ATPase

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10
Q

PPIs cause malabsorption of what vitamins and minerals?

A
  1. B12
  2. Ca
  3. Fe
  4. Zn
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11
Q

Intake of PPIs affect the bioavailability of these drugs

A
  1. Ketoconazole
  2. Ampicillin
  3. Ferrous salts
  4. Digoxin
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12
Q

[PPI]

Use with caution in hepatically -mpaired patients

A
  1. Pantoprazole
  2. Esomeprazole
  3. Omeprazole
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13
Q

[PPI]

Use with caution in renally-impaired patients

A
  1. Omeprazole

2. Pantoprazole

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14
Q

[PPI]

Among all PPIs which has the least drug-drug interaction

A

Pantoprazole

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15
Q

Prostaglandin 1 analogue that is useful in preventing NSAID-induced gastric mucosal injury

A

Misoprostol

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16
Q

Mucosal protective agent that both coats the ulcerated tissue + antimicrobial effect + sequesters enterotoxin

A

Bismuth salicylate

17
Q

[mucosal protective agent]

Causes darkening of tongue, ataxia, headaches, confusion, seizures

A

bismuth salicylate

18
Q

What are the components of Quadruple Therapy for eradication of H. pylori?

A

TOMB

Tetracyclin, Omeprazole, Metronidazole, Bismuth Salicylate

19
Q

What are the components of Bismuth Therapy for eradication of H. pylori?

A

BMT

Bismuth salicylate
Metronidazole
Tetracycline

20
Q

___ are prokinetic agent that block D2 receptors

A
  1. Metoclopramide

2. Domperidone

21
Q

____ is a macrolide that stimulates motilin receptors

A

Erythromycin

22
Q

What is the drug of choice for diabetic gastroparesis

A

Metoclopramide

23
Q

A prokinetic drug that does not cross the BBB (less toxic)

A

Domperidone

24
Q

Antibiotic given as bowel preparation prior to surgery since it binds to the motilin receptor

A

erythromycin

25
Q

[laxatives]

bulk forming, indigestible, hydrophillic colloids that absorb water

tx: constipation

A

psyllium

Methylcellulose, polycarbophil, maltodextrin

26
Q

[laxatives]

stool softener, permits water and lipids to penetrate

tx: constipation

A

Mineral oil, docusuate, glycerine suppository

27
Q

[laxatives]

osmotic, soluble but not absorbable compounds resulting to increased stoll liquidity

A

lactulose

28
Q

mainstay treatment for hepatic encephalopathy

A

lactulose

29
Q

lactulose cause these electrolyte imbalance

A
  1. Hyperphosphatemia
  2. Hypernatremia
  3. Hypermagnesemia
  4. Hypocalcemia
  5. Hypokalemia
30
Q

[laxatives]

stimulan/cathartic that directly stimulate enteric NS and colonic electrolyte

A

bisacodyl

31
Q

Benign colonic disorder wherein a brown lipofuscin pigment accumulates due to intake of Senna

A

melanosis coli

32
Q

[Antidiarrheal agent]

activates opioid receptors in the enteric NS, slows motility of GIT

A

Diphenoxylate, loperamide, difenoxin

33
Q

This antidiarrheal agent can cause paralytic ileus if given to children less than 4 years of age

A

Diphenoxylate

34
Q

Loperamide-induced paralytic ileus can be reversed by this drug

A

Bethanechol

35
Q

What is the principal metabolite of diphenoxylate

A

difenoxin

36
Q

Anti emetic drug that acts antagonizes the 5HT3 receptor

A

Ondansetron

37
Q

[Drugs used in IBD]

An immunomodulator used only for mild controlled cases

A

Mesalamine, Sulfasalazine

38
Q

Cite examples of TNF antagonist

A
  1. Adalinumab
  2. Certolizumab
  3. Infliximab

Pharmacology (35 decks)

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