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Pharmacology > Drugs for Angina Pectoris > Flashcards

Drugs for Angina Pectoris Flashcards

1
Q

[Nitrates]

ultrashort-acting, used in CYANIDE poisoning

A

amyl nitrite

cause oxidation of Fe in Hgb to Fe3 in methemoglobin

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2
Q

What is the drug of choice in treating methemoglobinemia?

A

low dose methylene blue

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3
Q

Cyanide affects what part of the ETC?

A

Complex IV (cytochrome oxidase)

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4
Q

What is the antidote for cyanide poisoning?

A

Lilly Cyanide kiit

  1. Inhaled amyl nitrite
  2. IV Na nitrite
  3. IV Na thiosulfate
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5
Q

[Nitrates]

short acting, used in ACS

more of a venodilator

A

Nitroglycerin

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6
Q

ISDN/ISMN is not given with this drug class due to dangerous hypotension as its combined effect

A

PDE inhibitors

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7
Q

[Nitrates]

that decrease platelet aggregation, first pass effect approximately 90%

A

Nitroglycerin - ISMN

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8
Q

Between ISMN and ISDN

which does not undergo FPE?

A

ISMN

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9
Q

Nitrates inhibit what enzyme?

A

guanylyl cyclase

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10
Q

What blood vessel is affected when patients taking nitrates experience throbbing headaches?

A

meningeal blood vessel vasodilation

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11
Q

CCB that cause gingival hyperplasia?

A

verapamil

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12
Q

CCB used to treat vasospasm and Reynaud Phenomenon?

A

Diltiazem

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13
Q

What is the DOC for prinzmetal angina?

A

CC- Diltiazem

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14
Q

what calcium channels are blocked by CCBs?

A

L-type calcium channels

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15
Q

Drugs that can cause gingival hyperplasia?

A

Nifedipine
Cyclosporine
Phenytoin
Verapamil

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16
Q

[beta blockers]

reduces renin release; used in glaucoma

A

propanolol

17
Q

[metabolism modifier]

inhibit beta oxidation by inhibiting 3 ketoacyl-CoA thoilase which enhances glucose oxidation

A

trimetazidine

18
Q

[metabolism modifier]

cause restless leg syndrome

A

trimetazidine

also a cytoprotective agen

19
Q

[metabolism modifier]

interacts with MAOl; prevent decrease in ATP in ischemic/hypoxic states

A

trimetazidine

20
Q

[metabolism modifier]

reduces late, prolonged Na current in myocardial cells

A

Ranolazine

21
Q

[metabolism modifier]

used for prophylaxis of angina; concentration increased by CYP 3A4

A

Ranolazone

22
Q

[metabolism modifier]

funnt Na current SA node inhibitor

A

ivabradine

23
Q

[metabolism modifier]

very effective in decreasing heart rate without decreasing bp

A

ivabradine

24
Q

[metabolism modifier]

prophylaxis of angina, decrease hyperpolarization-induced inward pacemaker current

A

ivabradine

Pharmacology (35 decks)

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