Drugs for Angina Pectoris

Question 1

[Nitrates]

ultrashort-acting, used in CYANIDE poisoning

Answer 1

amyl nitrite

cause oxidation of Fe in Hgb to Fe3 in methemoglobin

Question 2

What is the drug of choice in treating methemoglobinemia?

Answer 2

low dose methylene blue

Question 3

Cyanide affects what part of the ETC?

Answer 3

Complex IV (cytochrome oxidase)

Question 4

What is the antidote for cyanide poisoning?

Answer 4

Lilly Cyanide kiit

1. Inhaled amyl nitrite
2. IV Na nitrite
3. IV Na thiosulfate

Question 5

[Nitrates]

short acting, used in ACS

more of a venodilator

Answer 5

Nitroglycerin

Question 6

ISDN/ISMN is not given with this drug class due to dangerous hypotension as its combined effect

Answer 6

PDE inhibitors

Question 7

[Nitrates]

that decrease platelet aggregation, first pass effect approximately 90%

Answer 7

Nitroglycerin - ISMN

Question 8

Between ISMN and ISDN

which does not undergo FPE?

Answer 8

ISMN

Question 9

Nitrates inhibit what enzyme?

Answer 9

guanylyl cyclase

Question 10

What blood vessel is affected when patients taking nitrates experience throbbing headaches?

Answer 10

meningeal blood vessel vasodilation

Question 11

CCB that cause gingival hyperplasia?

Answer 11

verapamil

Question 12

CCB used to treat vasospasm and Reynaud Phenomenon?

Answer 12

Diltiazem

Question 13

What is the DOC for prinzmetal angina?

Answer 13

CC- Diltiazem

Question 14

what calcium channels are blocked by CCBs?

Answer 14

L-type calcium channels

Question 15

Drugs that can cause gingival hyperplasia?

Answer 15

Nifedipine
Cyclosporine
Phenytoin
Verapamil

Question 16

[beta blockers]

reduces renin release; used in glaucoma

Answer 16

propanolol

Question 17

[metabolism modifier]

inhibit beta oxidation by inhibiting 3 ketoacyl-CoA thoilase which enhances glucose oxidation

Answer 17

trimetazidine

Question 18

[metabolism modifier]

cause restless leg syndrome

Answer 18

trimetazidine

also a cytoprotective agen

Question 19

[metabolism modifier]

interacts with MAOl; prevent decrease in ATP in ischemic/hypoxic states

Answer 19

trimetazidine

Question 20

[metabolism modifier]

reduces late, prolonged Na current in myocardial cells

Answer 20

Ranolazine

Question 21

[metabolism modifier]

used for prophylaxis of angina; concentration increased by CYP 3A4

Answer 21

Ranolazone

Question 22

[metabolism modifier]

funnt Na current SA node inhibitor

Answer 22

ivabradine

Question 23

[metabolism modifier]

very effective in decreasing heart rate without decreasing bp

Answer 23

ivabradine

Question 24

[metabolism modifier]

prophylaxis of angina, decrease hyperpolarization-induced inward pacemaker current

Answer 24

ivabradine