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Pharmacology > Asthma Drugs > Flashcards

Asthma Drugs Flashcards

1
Q

The drug of choice for acute asthma attacks

A

beta 2 selective agonist (short acting)

Salbutamol/Albuterol

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2
Q

This drug class can precipitate arrhythmias in patients with concurrent COPD and heart disease

A

Beta 2 selective agonist (short acting)

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3
Q

Terbutaline is what drug class?

A

Beta 2 selective agonist (short acting) can be given inhalational, PO, IV

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4
Q

DOC for asthma prophylaxis

A

beta 2 selective (long acting)

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5
Q

Cite examples of long acting SABA

A 
Formoterol
Arformoterol
Bambuterol
Cleneterol
Vilanterol
Indacaterol
Olodaterol
Salmeterol
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6
Q

Asthma drug that blocks muscarinic receptors in bronchial smooth muscle

A

muscarinic receptor antagonist

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7
Q

This drug class has no effect of chronic inflammation aspect of bronchial asthma

A

Antimuscarinic receptors

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8
Q

[Muscarinic receptor antagonist]

does not cross the BBB, few central effects

A

Glycopyrronium

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9
Q

[Muscarinic receptor antagonist]

used as anti-spasmodic, reduce salivation with some anesthetics

A

glycopyrronium

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10
Q

This drug class has a MOA of phosphodiesterase inhibition and adenosine receptor antagonist leading to bronchodilation

A

Theophylline

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11
Q

This drug is used as prophylaxis against nocturnal attacks

A

Theophylline

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12
Q

Drug used for intermittent claudication

A

pentoxyfylline

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13
Q

What is the antidote for methylxanthine overdose?

A

betablockers

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14
Q

Examples of Mast cell stabilizer

A
  1. Cromolyn
  2. Nedocromil
  3. Lodoxamide
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15
Q

Anti asthma drug but can also induce cough at SE

A

Mast cell stabilizers

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16
Q

Off label use of mast cell stabilizers

A
  1. Food allergy

2. IBD

17
Q

What is the drug of choice for asthma prophylaxis?

A

Fluticasone

18
Q

What is the first line treatment for moderate to severe BA, COPD, AR,

A

Corticosteroid

19
Q

What is the drug of choice for status asthmaticus?

A
  1. IV prednisolone

2. Hydrocortisone

20
Q

What is the active metabolite of prednisone?

A

prednisolone

21
Q

Among the corticosteroids, which has the lowest systemic steroid toxicity?

A

Ciclesonide

22
Q

Cite example of lipooxygenase inhibitor (5-lipooxygenase)

A

Zileuton

23
Q

What are the drug used for exercise-, antigen-, and aspirin-induced bronchospasm?

A

Zileuton (LT synthesis inhibitor), LTRA (-lukasts)

24
Q

Drug class that can cause transaminitis

A

Zilueton

25
Q

Drug class that has no bronchodilator action and not recommended for acute BA attacks

A

Zileuton (Lipooxygenase inhibitors) and LTRA (-lukasts)

26
Q

Cite examples of LTRA?

A
  1. Montelukast
  2. Pranlukast
  3. Zafirlukast
27
Q

Montelukast block what receptor?

A

Cysteinyl leukotriene-1 for LTC4, LTD4, LTE4

28
Q

Antiasthma drugs that can cause Churg-Strauss Syndome

A

LTRA (-lukasts)

29
Q

Anti-IgE antibody that binds IgE on Mast cells

A

Omalizumab

30
Q

What is the antidote for acetaminophen toxicity?

A

NAC

31
Q

Drug for cough that is an expectorant by acting as an irritant to gastric vagal receptors

A

Guiafenesin

32
Q

Cite examples of antitussive

A
  1. Codeine

2. Dextromethorphan

33
Q

Drug thatn can be used for painful cough of neoplasia or pleural disease, epiglottitis, in hemoptysis

has no antibacterial role

A

Antitussives

34
Q

Antitussive that has no addictive potential, no analgesic effect, less constipation, inhibition of mucociliary clearance

A

Dextromethorphan

35
Q

Example of non-opioid antitussive; acts through the receptors in the brainstem to inhibit cough

A

Butamirate citrate

36
Q

Peripherally acting antitussive; inhibits the afferent pathway that generate cough reflex

A

levodropropizine

37
Q

inhibits PDE III and inhibits CCB, potent anti-COX2 activity

A

Vitex negundo (Lagundi)

Pharmacology (35 decks)

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