Asthma Drugs Flashcards
The drug of choice for acute asthma attacks
beta 2 selective agonist (short acting)
Salbutamol/Albuterol
This drug class can precipitate arrhythmias in patients with concurrent COPD and heart disease
Beta 2 selective agonist (short acting)
Terbutaline is what drug class?
Beta 2 selective agonist (short acting) can be given inhalational, PO, IV
DOC for asthma prophylaxis
beta 2 selective (long acting)
Cite examples of long acting SABA
Formoterol Arformoterol Bambuterol Cleneterol Vilanterol Indacaterol Olodaterol Salmeterol
Asthma drug that blocks muscarinic receptors in bronchial smooth muscle
muscarinic receptor antagonist
This drug class has no effect of chronic inflammation aspect of bronchial asthma
Antimuscarinic receptors
[Muscarinic receptor antagonist]
does not cross the BBB, few central effects
Glycopyrronium
[Muscarinic receptor antagonist]
used as anti-spasmodic, reduce salivation with some anesthetics
glycopyrronium
This drug class has a MOA of phosphodiesterase inhibition and adenosine receptor antagonist leading to bronchodilation
Theophylline
This drug is used as prophylaxis against nocturnal attacks
Theophylline
Drug used for intermittent claudication
pentoxyfylline
What is the antidote for methylxanthine overdose?
betablockers
Examples of Mast cell stabilizer
- Cromolyn
- Nedocromil
- Lodoxamide
Anti asthma drug but can also induce cough at SE
Mast cell stabilizers
Off label use of mast cell stabilizers
- Food allergy
2. IBD
What is the drug of choice for asthma prophylaxis?
Fluticasone
What is the first line treatment for moderate to severe BA, COPD, AR,
Corticosteroid
What is the drug of choice for status asthmaticus?
- IV prednisolone
2. Hydrocortisone
What is the active metabolite of prednisone?
prednisolone
Among the corticosteroids, which has the lowest systemic steroid toxicity?
Ciclesonide
Cite example of lipooxygenase inhibitor (5-lipooxygenase)
Zileuton
What are the drug used for exercise-, antigen-, and aspirin-induced bronchospasm?
Zileuton (LT synthesis inhibitor), LTRA (-lukasts)
Drug class that can cause transaminitis
Zilueton
Drug class that has no bronchodilator action and not recommended for acute BA attacks
Zileuton (Lipooxygenase inhibitors) and LTRA (-lukasts)
Cite examples of LTRA?
- Montelukast
- Pranlukast
- Zafirlukast
Montelukast block what receptor?
Cysteinyl leukotriene-1 for LTC4, LTD4, LTE4
Antiasthma drugs that can cause Churg-Strauss Syndome
LTRA (-lukasts)
Anti-IgE antibody that binds IgE on Mast cells
Omalizumab
What is the antidote for acetaminophen toxicity?
NAC
Drug for cough that is an expectorant by acting as an irritant to gastric vagal receptors
Guiafenesin
Cite examples of antitussive
- Codeine
2. Dextromethorphan
Drug thatn can be used for painful cough of neoplasia or pleural disease, epiglottitis, in hemoptysis
has no antibacterial role
Antitussives
Antitussive that has no addictive potential, no analgesic effect, less constipation, inhibition of mucociliary clearance
Dextromethorphan
Example of non-opioid antitussive; acts through the receptors in the brainstem to inhibit cough
Butamirate citrate
Peripherally acting antitussive; inhibits the afferent pathway that generate cough reflex
levodropropizine
inhibits PDE III and inhibits CCB, potent anti-COX2 activity
Vitex negundo (Lagundi)
