Prostaglandins and other Eicosanoids Flashcards
[Families of eicosanoids]
Straight-chain derived
leukotrienes
[Families of eicosanoids]
cyclic derivates
- prostacyclin
- prostaglandin
- thromboxane
[Cyclooxygenase Isoforms]
found primarily in inflammatory cells; in the vascular epithelium and of prostaglandins important in renal function
COX2
[Guess the eicosanoid]
leukocyte chemotaxis
LTB4
[Guess the eicosanoid]
slow reacting substance of anaphylaxis
LTC4
LTD4
LTE4
[Guess the eicosanoid]
vascular smooth muscle relaxation, protective effects in gastric mucosa, maintains PDA
PGE1
[Guess the eicosanoid]
Vascular smooth muscle relaxation, maintains PDA, increases uterine tone
PGE2
[Guess the eicosanoid]
vascular smooth muscle relaxation (peripheral, pulmonary, coronary)
PGI2
[Guess the eicosanoid]
Increases uterine tone, decreases IOP
PGF 2 alpha
[Guess the eicosanoid]
platelet aggregation
TXA2
PGE1 analog used for the prevention of NSAID-induced gastric mucosal injury
misprostol
PGE1 analog associated with Moebius sequence
misorpostol
Misoprostol is combined with these drugs. Its considered as safe abortifacient.
- Mifepristone o2
2. Methotrexate
PGE 1 analog used to maintain PDA patency
Alprostadil
PGE1 anaolog that is injected into the cavernosa for erectule dysfunction
Alprostadil
Example of Prostaglandin E2 analog
Dinoprostone
Example of Prostaglandin E1 analog
Alprostadil
At low concentrations, Dinoprostone ___ (contract/relax) the uterus
contract
At high concentrations, Dinoprostone ___ (contract/relax) the uterus
relax
Drug used to soften cervix at term before induction with oxytocin
dinoprostone
Prostaglanding analog used as cervical ripening agent
dinoprostone
A prostaglanding F2 alpha analog used to control postpartum hemorrhage or refractory PPH
Carboprost
What are the examples of prostaglanding F2 alpha analog?
- Carboprost
- Bimatoprost
- Travoprost
- Unoprostone
- Latanaprost
Prostaglandin I2 analog used for pulmonary hypertension
Epoprostenol
Drug of choice to reduce platelet aggregation in dialysis machine
Treprostonol
Prostaglanding F2 alpha analog used to treat glaucoma
latanaprost
What is the mechanism of action of latanaprost in treating glaucoma?
Increases the outflow of aqueous humor, reduces intraocular pressure reduction
What are the prominent side effects of latanaprost in the eyes?
- Iris color alteration
2. Permanent eye color change
PDE5 inhibitor used to treat erectile dysfunction, arterial hypertension, and reynaud’s phenomenon
Sildenafil
do not take with nitrates
