Prostaglandins and other Eicosanoids

Question 1

[Families of eicosanoids]

Straight-chain derived

Answer 1

leukotrienes

Question 2

[Families of eicosanoids]

cyclic derivates

Answer 2

1. prostacyclin
2. prostaglandin
3. thromboxane

Question 3

[Cyclooxygenase Isoforms]

found primarily in inflammatory cells; in the vascular epithelium and of prostaglandins important in renal function

Answer 3

COX2

Question 4

[Guess the eicosanoid]

leukocyte chemotaxis

Answer 4

LTB4

Question 5

[Guess the eicosanoid]

slow reacting substance of anaphylaxis

Answer 5

LTC4
LTD4
LTE4

Question 6

[Guess the eicosanoid]

vascular smooth muscle relaxation, protective effects in gastric mucosa, maintains PDA

Answer 6

PGE1

Question 7

[Guess the eicosanoid]

Vascular smooth muscle relaxation, maintains PDA, increases uterine tone

Answer 7

PGE2

Question 8

[Guess the eicosanoid]

vascular smooth muscle relaxation (peripheral, pulmonary, coronary)

Answer 8

PGI2

Question 9

[Guess the eicosanoid]

Increases uterine tone, decreases IOP

Answer 9

PGF 2 alpha

Question 10

[Guess the eicosanoid]

platelet aggregation

Answer 10

TXA2

Question 11

PGE1 analog used for the prevention of NSAID-induced gastric mucosal injury

Answer 11

misprostol

Question 12

PGE1 analog associated with Moebius sequence

Answer 12

misorpostol

Question 13

Misoprostol is combined with these drugs. Its considered as safe abortifacient.

Answer 13

1. Mifepristone o2

2. Methotrexate

Question 14

PGE 1 analog used to maintain PDA patency

Answer 14

Alprostadil

Question 15

PGE1 anaolog that is injected into the cavernosa for erectule dysfunction

Answer 15

Alprostadil

Question 16

Example of Prostaglandin E2 analog

Answer 16

Dinoprostone

Question 17

Example of Prostaglandin E1 analog

Answer 17

Alprostadil

Question 18

At low concentrations, Dinoprostone ___ (contract/relax) the uterus

Answer 18

contract

Question 19

At high concentrations, Dinoprostone ___ (contract/relax) the uterus

Answer 19

relax

Question 20

Drug used to soften cervix at term before induction with oxytocin

Answer 20

dinoprostone

Question 21

Prostaglanding analog used as cervical ripening agent

Answer 21

dinoprostone

Question 22

A prostaglanding F2 alpha analog used to control postpartum hemorrhage or refractory PPH

Answer 22

Carboprost

Question 23

What are the examples of prostaglanding F2 alpha analog?

Answer 23

1. Carboprost
2. Bimatoprost
3. Travoprost
4. Unoprostone
5. Latanaprost

Question 24

Prostaglandin I2 analog used for pulmonary hypertension

Answer 24

Epoprostenol

Question 25

Drug of choice to reduce platelet aggregation in dialysis machine

Answer 25

Treprostonol

Question 26

Prostaglanding F2 alpha analog used to treat glaucoma

Answer 26

latanaprost

Question 27

What is the mechanism of action of latanaprost in treating glaucoma?

Answer 27

Increases the outflow of aqueous humor, reduces intraocular pressure reduction

Question 28

What are the prominent side effects of latanaprost in the eyes?

Answer 28

1. Iris color alteration

2. Permanent eye color change

Question 29

PDE5 inhibitor used to treat erectile dysfunction, arterial hypertension, and reynaud’s phenomenon

Answer 29

Sildenafil

do not take with nitrates