NSAID, Acetaminophen Flashcards
Cite example of salicylates
Aspirin
Examples of NONSELECTIVE NSAIDS
- Ibuprofen
- Indomethacin
- Ketorolac
- Piroxicam
Examples of COX2 Selective NSAIDS
- Celecoxib
- Etoricoxib
- Parecoxib
____ is a non-selective irreversible COX 1 and 2 inhibitor.
Reduces platelet production of TXA2
Aspirin
What is the drug of choice for kawasaki disease?
aspirin
In low doses, aspirin <300mg undergoes ___ order kinetics
first order
Low dose is effective in reducing platelet aggregation
In high doses, aspirin 2400-4000 mg, undergoes ___ order kinetics
zero order
High dose is an effective anti-inflammatory drug
Contraindicated in gout since it prevents uric acid excretion
Aspirin
What is the lethal dose of aspirin?
30g (Aspirin 500mg x 60 tablets)
What is the toxic dose of aspirin?
150mg/kg
[NSAIDS chemical grouping]
Sulfoxide
Sulindac
[NSAIDS chemical grouping]
Fenamate derivatives
Meclofenamic acid, mefenamic acid, diclofenac
[NSAIDS chemical grouping]
Pyrrolealkanoic acid derivative
tolmetin
[NSAIDS chemical grouping]
propionic acid derivative
Ibuprofen, Naproxen, Fenoprofen, Carprofen, Ketoprofen
____ prevents NSAID induced gastritis
Misoprostol
NSAIDs used to close PDA
Ibuprofen
Indomethacin
IV NSAD that is non-selective, reversible COX1 and COX2 inhibitor
Ketorolac
Dexketoprofen
NSAID used for post-surgical analgesic control (moderate to severe)
Ketorolac
Ketorolac is limited to ___ hours only due to possible GI and renal damage
72 hours
This has the highest anti-inflammatory effect compared to other NSAIDs
Indomethacin
____ is a preferentially COX2 selective inhibitor
Meloxicam
Among the COX2 inhibitors, this has a side effect of MI and stroke
Rofecobib
Veldecoxib
Paracetamol can cause renal damage specifically ____
renal papillary necrosis
Phenacitin, an acetaminophen, causes what damage in the kidney
interstitial nephritis
What is the preferred antipyretics in children?
paracetamol
What is the antidote of paracetamol toxicity
N-acetylcysteine
Paracetamol overdose preferentially which part of the hepatic lobule?
Centrilobular region (zone III)
What is a good gastric decontaminant for paracetamol overdose?
activated charcoal
Diclofenac is administered with this prostaglandin analogue can lead to diarrhea
misoprostol
___ is used in intraoperative miosis
flurbiprofen
what is the only NOT ACIDIC NSAID available
Nabumetone
What NSAID has the longest half life
Oxaprozin (56 hours)
What is the effect of NSAID in the GFR?
It reduces the GFR due to vasodilation of the Afferent arteriole
What NSAID does not cause a decrease in GFR
Sulindac
