NSAID, Acetaminophen

Question 1

Cite example of salicylates

Answer 1

Aspirin

Question 2

Examples of NONSELECTIVE NSAIDS

Answer 2

1. Ibuprofen
2. Indomethacin
3. Ketorolac
4. Piroxicam

Question 3

Examples of COX2 Selective NSAIDS

Answer 3

1. Celecoxib
2. Etoricoxib
3. Parecoxib

Question 4

____ is a non-selective irreversible COX 1 and 2 inhibitor.

Reduces platelet production of TXA2

Answer 4

Aspirin

Question 5

What is the drug of choice for kawasaki disease?

Answer 5

aspirin

Question 6

In low doses, aspirin <300mg undergoes ___ order kinetics

Answer 6

first order

Low dose is effective in reducing platelet aggregation

Question 7

In high doses, aspirin 2400-4000 mg, undergoes ___ order kinetics

Answer 7

zero order

High dose is an effective anti-inflammatory drug

Question 8

Contraindicated in gout since it prevents uric acid excretion

Answer 8

Aspirin

Question 9

What is the lethal dose of aspirin?

Answer 9

30g (Aspirin 500mg x 60 tablets)

Question 10

What is the toxic dose of aspirin?

Answer 10

150mg/kg

Question 11

[NSAIDS chemical grouping]

Sulfoxide

Answer 11

Sulindac

Question 12

[NSAIDS chemical grouping]

Fenamate derivatives

Answer 12

Meclofenamic acid, mefenamic acid, diclofenac

Question 13

[NSAIDS chemical grouping]

Pyrrolealkanoic acid derivative

Answer 13

tolmetin

Question 14

[NSAIDS chemical grouping]

propionic acid derivative

Answer 14

Ibuprofen, Naproxen, Fenoprofen, Carprofen, Ketoprofen

Question 15

____ prevents NSAID induced gastritis

Answer 15

Misoprostol

Question 16

NSAIDs used to close PDA

Answer 16

Ibuprofen

Indomethacin

Question 17

IV NSAD that is non-selective, reversible COX1 and COX2 inhibitor

Answer 17

Ketorolac

Dexketoprofen

Question 18

NSAID used for post-surgical analgesic control (moderate to severe)

Answer 18

Ketorolac

Question 19

Ketorolac is limited to ___ hours only due to possible GI and renal damage

Answer 19

72 hours

Question 20

This has the highest anti-inflammatory effect compared to other NSAIDs

Answer 20

Indomethacin

Question 21

____ is a preferentially COX2 selective inhibitor

Answer 21

Meloxicam

Question 22

Among the COX2 inhibitors, this has a side effect of MI and stroke

Answer 22

Rofecobib

Veldecoxib

Question 23

Paracetamol can cause renal damage specifically ____

Answer 23

renal papillary necrosis

Question 24

Phenacitin, an acetaminophen, causes what damage in the kidney

Answer 24

interstitial nephritis

Question 25

What is the preferred antipyretics in children?

Answer 25

paracetamol

Question 26

What is the antidote of paracetamol toxicity

Answer 26

N-acetylcysteine

Question 27

Paracetamol overdose preferentially which part of the hepatic lobule?

Answer 27

Centrilobular region (zone III)

Question 28

What is a good gastric decontaminant for paracetamol overdose?

Answer 28

activated charcoal

Question 29

Diclofenac is administered with this prostaglandin analogue can lead to diarrhea

Answer 29

misoprostol

Question 30

___ is used in intraoperative miosis

Answer 30

flurbiprofen

Question 31

what is the only NOT ACIDIC NSAID available

Answer 31

Nabumetone

Question 32

What NSAID has the longest half life

Answer 32

Oxaprozin (56 hours)

Question 33

What is the effect of NSAID in the GFR?

Answer 33

It reduces the GFR due to vasodilation of the Afferent arteriole

Question 34

What NSAID does not cause a decrease in GFR

Answer 34

Sulindac