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Pharmacology > Hypothalamic and Pituitary Drugs > Flashcards

Hypothalamic and Pituitary Drugs Flashcards

1
Q

Among the pituitary hormones, which are potent vasoconstrictors

A
  1. Vassopressin
  2. Oxytocin

All posterior pituitary

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2
Q

[Growth Hormone]

Drug with agonist action

A
  1. Somatropin

2. Mecasermin

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3
Q

[Growth Hormone]

Drug with antagonist action

A
  1. Octreotide

2. Pegvisomant

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4
Q

[Gonadotropin]

Drug with LH agonist action

A
  1. Lutropin

2. hCG

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5
Q

[Gonadotropin]

Drug with FSH agonist action

A

Follitropin

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6
Q

[Gonadotropin]

Drug with mixed LH and FSH agonist action

A

Menotropin

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7
Q

Drug that has a prolactin antagonist action

A

Bromocriptine (D2 dopamine agonist)

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8
Q

Drug with GnRH Agonist action

A

Gonadorelin

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9
Q

Drug with GnRH receptor agonist action

A

Leuprolide

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10
Q

Drug with GnRH receptor antagonist action

A

Ganirelix

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11
Q

Drug with ADH agonist action

A

Desmopressin

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12
Q

Drug with ADH antagonist action

A

Conivaptan

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13
Q

Drug with oxytocin agonist action

A

Oxytocin

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14
Q

Drug with Oxytocin antagonist action

A

Atosiban

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15
Q

Drug that increases the release of IGF-1 in the liver and cartilage

A

Somatropin

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16
Q

DOC for patients with Turner, Noonan, Prader-Willi (with short stature)

A

Somatropin - recombinant growth hormine

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17
Q

DOC to improve GI function in patients who underwent intestinal resection that lead to malabsorption syndrome

A

Somatropin

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18
Q

Recombinant IGF-1 agonist; or patients unresponsive to GH therapy

A

Mecasermin

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19
Q

What drug can be given to patients with acromegaly?

A

Pegvisomant

20
Q

DOC for GH-secreting pituitary adenoma

A

Octreotide

Also be given for gastrinoma, glucagonoma, carcinoid

21
Q

[Ovulation Induction Protocol]

Follicle development is driven by daily injections of these drugs

A
  1. Menotropins
  2. FSH
  3. FSH analog
22
Q

[Ovulation Induction Protocol]

What is injected to induce on the final stage of oocyte maturation

A
  1. LH or

2. hCG

23
Q

What is the DOC for infertility due to hypogonadotropic hypogonadism in men?

A
  1. Follitropin
24
Q

A FSH analog that is a purified preparation from the urine of postmenopausal women

A

urofollitropin

25
Q

DOC for initiation of ovulation during controlled ovarian hyperstimulation

A

Choriogonadotropin

26
Q

DOC for ovarian follicle development with hypogonadotropic hypogonadism in women

A

Choriogonadotropin alpha

27
Q

Intermittent administration of leuprolide can lead to ____ (increase/decrease) of LH and FSH

A

Increase

28
Q

Continous administration of Leuprolide can lead to ____ (increase/decrease) of LH and FSH

A

Decrease

due to down regulation of GnRH receptors in the pituitary cells

29
Q

What is the DOC for patients with precocious puberty

A

Leuprolide

30
Q

Advanced prostate CA can be injected with this drug class;

it can lead to temporary exacerbation or tumor flare up

A
  1. GnRH analog (Leuprolide)
31
Q

What will you give for patients experiencing apoplexy and blindness during the first week of therapy withleuprolide?

A

Give FLUTAMIDE (androgen receptor antagonist)

32
Q

What is the DOC to prevent premature LH surge during controlled ovarian hyperstimulation

A

GnRH antagonist

Ganirelix

33
Q

Advanced prostate CA can be injected with this drug class;

doe not cause tumor flare up

A

GnRH antagonist

Degarelix

34
Q

Dopamine agonist that inhibits prolactin release from the pituitary gland; slightly inhibits GH release

A
  1. Bromocroptine

2. Pergolide

35
Q

Method of administration of Bromocriptine in women with hyperprolactinemia

A

Vaginally

36
Q

Bromocriptine is contraindicated in patients with ____

A

psychotic illness

37
Q

____ is a rare disorder characterized by burning and warmth of the extremities; SE of bromocriptine

A

Erythromelalgia

38
Q

What are the contraindications to giving oxytocin

A
  1. Fetal distress
  2. Prematurity
  3. Abnormal presentation
  4. CPD
  5. Predisposition for uterine rupture
39
Q

Drug that is an oxytocin receptor blocker

A

Atosiban

40
Q

Drug that is an agonist of peripheral oxytocin receptors

A

Carbetocin

41
Q

Desmopressin is selective for what ADH receptor

A

V2

42
Q

What ADH agonist is used to treat esophageal varices or colon diverticula

A

Desmopressin

Contracts vascular smooth muscle via V1 receptor leading to vasoconstriction

43
Q

[Diagnose]

polyuria, polydipsia, hypernatremia

A

Diabetes Insipidus

44
Q

ADH antagonist used to treat SIADH, Hyponatremia in hospitalized patients

A

Conivaptan

45
Q

What drug selectively inhibits V2 receptor

A
  1. Lixivaptan

2. Tolvaptan

Pharmacology (35 decks)

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