Succinylcholine (Anectine)

Question 1

Class / Action

Answer 1

Paralytic. Depolarizing Neuromuscular Blocker.

1. Prolongs depolarization of the muscle end plate
2. Induces skeletal muscle relaxation causing onset of flaccid paralysis in less than 1min
3. Has no effect on consciousness, pain threshold, or cerebration

Question 2

Onset / Duration of Action

Answer 2

Onset IV/IO: 30-60sec IM: 2-3min / Duration of 4-10min

Question 3

Indications

Answer 3

To facilitate endotracheal intubation in patients with an intact gag reflex

Question 4

Contraindications

Answer 4

1. Known Hypersensitivity
2. Acute Glaucoma, penetrating eye injuries
3. Suspected Hyperkalemia
4. 24hrs or more post-burn
5. 7days or more post-Crush Injury Syndrome (CIS)

Question 5

Precautions

Answer 5

1. Changes in cardiac rhythm may result from Vargas stimulation
2. CAUTION In patients with possible increased ICP

Question 6

Dosages / Administration

Answer 6

1. ADULT: 1.5mg/kg IV/IO. May use IM if IV/IO is unattainable; Double to IV/IO Dose.
2. PEDS: 2mg/kg IV/IO

Question 7

Adverse Reactions

Answer 7

1. Prolonged muscle relaxation, Prolonged respiratory depression or apnea, Bradycardia, Tachycardia, Hypertension, Hypotension, Arrhythmias, Excessive salivation.
2. Potential increase in ICP with second and third doses.