Ibuprofen

Question 1

Class / Action

Answer 1

Non-Steroidal Anti-Inflammatory Drug (NSAID)

1. The exact mechanism of action is unknown
2. Its pharmacological effects are believed to be d/t the inhibition of CycloOxygenase-2 (COX-2) which decrease the synthesis of prostaglandins involved in mediating inflammation, pain, fever, and swelling
3. Antipyretic effects may be d/t action on the hypothalamus, resulting in an increased peripheral blood flow, vasodilation, and subsequent heat dissipation

Question 2

Onset / Duration of Action

Answer 2

PO: 30min Onset / PO: 3-4hrs Duration

Question 3

Indications

Answer 3

1. Pain Management

2. Fever

Question 4

Contraindications

Answer 4

1. Hypersensitivity

2. Severe Liver Disease

Question 5

Precautions

Answer 5

1. Anemia
2. Renal Disease
3. Hypertension
4. Stomach Ulcers / Hx of

Question 6

Dosages / Administration

Answer 6

1. ADULT: 400-800mg PO with 8oz of water

2. PEDS: (6mo - 12years old): 10mg/kg PO

Question 7

Adverse Reactions

Answer 7

Nausea, Vomiting, Rash