Droperidol (Inapsine) #

Question 1

Class / Action

Answer 1

Anti-psychotic, Tranquilizer, Anti-nausea / Blocks dopamine (D2), muscarinic cholinergic, alpha adrenergic, and histamine (H1) receptors. Antipsychotic effects are thought to be a result of its selective blockade of postsynaptic dopamine receptors.

Question 2

Onset / Duration of Action

Answer 2

ONSET: 3-10min IV/IM
DURATION: 2-4hrs

Question 3

Indications

Answer 3

1. Aggressive or agitated behavior
2. Excited delirium
3. Severe nausea

Question 4

Contraindications

Answer 4

1. Depressed mental status
2. Parkinson’s disease
3. Prolonged QTI (>440ms in M & >450ms in F)

Question 5

Precautions

Answer 5

1. Elderly with dementia related psychosis
2. Utilize caution if combined with other medications that may prolong QTI (ondansetron)

Question 6

Dosages / Administration

Answer 6

Agitation/Chemical Sedation or Severe Nausea:
-Adult: 1.25-2.5mg IM or SIVP
-Peds: CONTACT MARY BRIDGE

Question 7

Adverse Reactions

Answer 7

1. Extrapyramidal symptoms
2. Parkinsonism
3. Dystonia
4. Akathisia
5. Tardive Dyskinesia
6. Neuroleptic Malignant Syndrome
7. QTI Prolongation & Potential for Torsades
8. HypOtension
9. Tachycardia
10. Apnea