Stephen-Johnson syndrome

Question 1

What is Stevens-Johnson syndrome?

Answer 1

A disproportional immune response (often to medication or viruses) that causes epidermal necrosis

Question 2

What types of medication commonly cause Stevens-Johnson syndrome?

Answer 2

Antiepileptics
Allopurinol
NSAIDs
Antibiotics

Question 3

What viruses commonly cause Stevens-Johnson syndrome?

Answer 3

Herpes simplex
Mycoplasma pneumonia
CMV
HIV
EBV
Hepatitis

Question 4

What is the presentation of Stevens-Johnson syndrome?

Answer 4

Flu-like symptoms - cough, fever, sore throat
Followed by a red-purple target shaped rash
Skin blistering and skin shedding

Question 5

Where in the body can be affected by Stevens-Johnson syndrome?

Answer 5

Eyes
Genital tract
Mouth
Skin
Lungs
Internal organs

Question 6

What is the management of Stevens-Johnson syndrome?

Answer 6

Supportive care
- Analgesia
- Antiseptics
- Ophthalmology input
- Nutritional care
Steriods
Immunoglobulins
Immunosuppressants

Question 7

What are the complications of Stevens-Johnson syndrome?

Answer 7

Secondary infection
Permenant skin damage
Visual complications
- Scarring
-Blindness