Precocious Puberty Flashcards
What is precocious puberty?
The onset of development of secondary sexual characteristics before age 8 in females, and age 9 in males
What are the two classifications of precocious puberty?
Gonadotrophin dependent precocious puberty
Gonadotrophin independent precocious puberty
What is the cause of gonadotrophin independent puberty?
Gonadal tumours
Adrenal or liver tumours
Congenital adrenal hyperplasia
What is the cause of gonadotrophin dependent puberty?
Mostly idiopathic (90%)
Brain tumours
Cranial radiotherapy
Structural brain damage
What are the FSH and LH levels in GDPP?
FSH and LH raised
What are the FSH and LH levels in GIPP?
FSH and LH low
What are the signs and symptoms of precocious puberty?
Rapid growth
Early development of secondary sexual characteristics
Menstruation in girls
Acne
Adult body odour
Emotional and behvaioural changes
What are the differentials of precocious puberty?
Thyroid disorders
Growth hormone excess
McCune-Albright syndrome
Adrenal tumours
What are the investigations for precocious puberty?
Oestrogen/testosterone levels
Adrenal androgen levels
Brain MRI
Pelvic ultrasound
Bone age assessment
What is the management of precocious puberty?
GnRH analogues to suspend progression
What are the complications of precocious puberty?
Premature fusion of bone growth plates and reduced adult height
Affected psychological wellbeing
