IBD Flashcards
What are the features of Crohn’s disease?
Affects entire GI tract
Skip lesions
Blood and mucus is less common
Transmural inflammation
Terminal ileum commonly affected
What are the features of Ulcerative colitis?
Colon and rectum only affected
Continuous inflammation
Blood and mucus in stool common
Only the superficial mucosa is affected
What are the general signs of IBD in children?
Diarrhoea
Weight loss
Bleeding
Abdominal pain
Anaemia
What are the additional symptoms of an IBD flare in children?
Fever
Malaise
Dehydration
What are the extra-intenstinal manifestations of IBD?
Finger clubbing
Erythema nodosum
Pyoderma gangernosum
Episcleritis
Inflammatory arthritis
Primary sclerosing cholangitis (UC)
What initial tests are performed in the diagnosis of IBD?
FBC
CRP/ESR
TFTs
LFTs
U&E
Faecal Calprotectin
What is the gold standard investigation for diagnosis of IBD?
Endoscopy
What is the first line management of acute Crohn’s?
Oral steroids
What is the second line management of acute Crohn’s?
Adding an immunosuppressant:
- Azathioprine
- Mercaptopurine
- Methotrexate
What is the first line medication to retain remission in Crohn’s?
Azathioprine or mercaptopurine
What are the alternative medications for retaining remission in Crohn’s?
Methotrexate
Infliximab
Adalimumab
What is the first line management to induce remission in UC?
An aminosalicylate (e.g mesalazine, sulfasalazine)
What is the second line management to induce remission in UC?
IV corticosteroids
IV ciclosporin
What is the first line medication to retain remission in UC?
An aminosalicylate (e.g mesalazine, sulfasalazine)
What is the second line medication to retain remission in UC?
Azathioprine
Mercaptopurine
