Sodium and Potassium Balance Flashcards
Define osmolarity and give its units
Measure of the solute concentration in a solution (osmoles/liter)
What does osmolarity depend on?
The number of dissolved particles
As the number of dissolved particles increases what happens to osmolarity?
It also increases
What is normal plasma osmolarity?
285-295 mosmol/L
What is the most prevalent solute in the ECF?
Sodium
What is the osmolarity of sodium in the ECF?
140 mmol/L
When sodium levels are normal what happens to desire to intake sodium?
Its supressed
What structure suppresses or stimulates sodium intake?
Lateral parabrachial nucleus
What receptors are involved in suppressing sodium intake?
Serotonin and glutamate
What receptors are involved in stimulating sodium intake?
GABA and opioids
What are the 2 mechanisms involved in sodium intake? Briefly describe them
Central mechanism- involves lateral parabrachial nucleus
Peripheral mechanism- involves taste
How does the peripheral mechanism for sodium intake work?
When we have low levels of salt in our body foods with salt will taste more appetising
Where does most sodium reabsorption occur?
PCT (67%)
What happens to GFR and renal blood flow as MAP increases
GFR and renal blood flow will increase proportionally to MAP until a certain point but then they will plateau
As the BP and amount of sodium entering the nephron increases, what happens in the DCT to reduce perfusion pressure and GFR?
High sodium levels are detected by specialised macula densa cells in the juxtoglomerular apparatus
There is increased sodium/chloride uptake via triple transporter
Adenosine is released from macula densa cells
Detected by extraglomerular mesangial cells
Adenosine also reduces renin production
Promotes afferent SMC contraction
Reduces perfusion pressure and so GFR
In the DCT what specialised cells detect high sodium levels?
Macula densa cells in the juxtoglomerular apparatus
Where is adenosine released from in the DCT?
From macula densa cells
What affect does increased sympathetic activity have on the nephron
Increased contraction of the afferent arteriole
Stimulates sodium uptake by PCT cells
Stimulates cells of the juxtaglomerular apparatus to produce renin, renin leads to angiotensin II production, this stimulates cells of the PCT to take up sodium
Stimulates adrenal glands to produce aldosterone, aldosterone stimulates sodium uptake in the distal DCT and collecting duct
What hormone does renin increase production of?
Angiotensin II
What effect does angiotensin II have on the PCT?
Stimulates cells to take up sodium
What hormone stimulates production of aldosterone?
Angiotensin II
How does anti naturietic peptide affect sodium levels?
Reduces sodium movement into the nephron and reduces reabsorption in the PCT, DCT and CD
How is sympathetic activity affected when blood pressure falls?
As blood pressure falls, fluid vol falls, which increases beta 1 sympathetic activity
How does sympathetic activity affect renin production?
Increases it
How does blood pressure falling affect ANP?
Increases ANP
How is sympathetic activity affected when blood pressure rises?
As blood pressure rises, fluid vol rises, which decreases beta 1 sympathetic activity
What type of hormone is aldosterone?
Steroid
Where is aldosterone synthesised and released?
From the adrenal cortex (zona glomerulosa)
What is aldosterone released in response to?
Angiotensin ll
Decrease in blood pressure (via baroreceptors)
How does angiotensin II specifically increase aldosterone synthesis?
Promotes synthesis of aldosterone synthase which carries out the final 2 steps in aldosterone synthesis
What does aldosterone stimulate?
Sodium reabsorption
Potassium secretion
What does aldosterone excess lead to?
Hypokalaemic alkalosis
How does aldosterone work?
Binds to mineralocorticoid receptor
Aldosterone then binds to HSP90, which causes HSP90 to be removed
The mineralocorticoid receptor now dimerises so it can translocate into the nucleus
It binds to DNA and stimulates production of mRNAs for genes under its control
What genes does aldosterone help upregulate?
The gene for the sodium channel in the collecting duct
The sodium potassium ATPase
What occurs physiologically in hypoaldosteronism?
Reabsorption of sodium in the distal nephron is reduced
Increased urinary loss of sodium
ECF volume falls
Increased renin, Ang II and ADH