PVD and Atherosclerosis Flashcards
What are modifiable risk factors in atherosclerosis development
Smoking Lipid intake BP Diabetes Obesity Sedentary lifestyle
What are non modifiable risk factors in atherosclerosis development
Age
Sex
Genetic background
How much do risk factors increase risk of developing atherosclerosis?
A lot, the risk also severely increases when multiple risk factors are involved
What layer does atherosclerosis start in?
Tunica intima
What are the stages of atherosclerosis progression called?
Coronary artery at lesion prone location Type 2 lesion Preatheroma Atheroma Fibroatheroma Complicated lesion
At what stage of atherosclerosis progression do foam cells form?
Type II lesion
What is the role of vascular endothelial cells in atherosclerosis
Barrier function (eg to lipoproteins Leukocyte recruitment
What is the role of monocyte/macrophages in atherosclerosis?
Foam cell formation
Cytokine and growth factor release
Major source of free radicals
Metalloproteinases
What is the role of platelets in atherosclerosis?
Thrombus generation
Cytokine and growth factor release
What is the role of platelets in vascular smooth muscle cells?
Migration and proliferation
Collagen synthesis
Remodelling and fibrous cap formation
What is the role of T lymphocytes in atherosclerosis?
Macrophage activation
What are the main inflammatory cells in atherosclerosis?
Macrophages
What are macrophages derived from in atherosclerosis?
Monocytes
What are the 2 main types of macrophages?
Inflammatory
Resident
What do inflammatory macrophages do?
They are adapted to kill microorgansims
What so resident macrophages do?
They are normally homeostatic and suppress inflammatory activity
What is the role of macrophages in the alveoli?
They are for surfactant lipid homeostasis
What is the role of macrophages in the osteoclasts?
For calcium and phosphate homeostasis
What is the role of macrophages in the spleen?
Iron homeostasis
Where is LDL synthesised?
In the liver
What is the role of LDL
Transport of cholesterol from the liver to the rest of the body (its bad cholesterol)
What is the role of HDL
Reverse cholesterol transport (from the body back to the liver)