Management of Specific Fractures Flashcards
What type of tissue is bone?
A specialised form of connective tissue
What are some of the main functions of bone?
Support
Protection
Locomotion
Haematopoiesis- reservoir of stem cells for RBC formation
Lipid and mineral storage- particularly calcium
What are the 3 regions of bone and where are they found?
Epiphysis (next to the metaphysis at the top and bottom of the bone)
Metaphysis (next to the diaphysis)
Diaphysis (in the middle of the bone)
What type of bone is found in the epiphysis?
Cancellous (spongy) bone
What type of bone is found in the cortex?
Cortical (compact) bone
What layer surround the bone?
Periosteum
What is the periosteum and why is it important?
It is the outermost layer that surrounds the bone, it is important as its involved with the blood supply to cancellous bone
What is the role of flat bones?
To protect organs
What is the role of long bones?
Facilitate movement
What is the role of short bones?
Provide stability and movement by articulation
What is special about short bones?
They don’t have a diaphysis
Where are sesamoid bones found?
Embedded in tendon
What are the types of bone?
Flat Long Short Sesamoid Irregular
What are the 2 forms of bone?
Woven
Lamellar
What type of bone is formed first?
Woven
Describe woven bone
A temporary structure with random arrangements of collagen
Describe lamellar bone
Has a stronger and more regular structure than woven bone
What is the role of ECM in bone?
Provides biochemical and mechanical support
What does ECM in bone contain?
Collagen type 1 and 5 (90% type 1)
Mineral salts
What are the cellular components of bone?
Osteoblasts
Osteocytes
Osteoclasts
Osteoprogenitor stem cells
What is the role of osteoblasts in bone?
Synthesis of uncalcified ECM
What is the role of osteoclasts in bone?
Resorb bone
What is special about osteoclasts?
One of the few multinucleated cells in the body
What are bone stem cells called?
Osteoprogenitor cells
What are the 2 methods of bone formation?
Endochondral
Intramembranous
Compare the blood supply of bone to cartilage
Blood supply to bone is a lot richer
Describe endochondral ossification briefly
Bone development from hyaline cartilage
Describe intramembranous ossification briefly
Formation of bone directly onto fibrous tissue (bone development from fibrous membrane)
What state are bones constantly in?
A state of remodelling
What is the role of osteoclasts? Why are they needed?
Bone removal, this is needed as it increases calcium levels in the body
What is the role of osteoblasts?
Bone synthesis
How are osteoblasts activated?
They have receptors for PTH, prostaglandins, vitamin D and cytokines that activate the process of bone sythesis