Pharmacology of Depression Flashcards
What are the mechanisms of action of sertraline, citalopram, and fluxotine
They inhibit the reuptake of serotonin by acting on the serotonin reuptake transporter
What are the main side effects of sertraline, citalopram, and fluxotine?
GI effects, insomnia, sexual dysfunction, anxiety
Which drugs prescribed for depression must be gradually discontinued when discontinued?
Sertraline, citalopram, venlafalxine, mirtazipine
What does sertraline partially inhibit?
CYP2D6 when given at high concs (150mg)
What is citalopram a mild antagonist of?
Muscarinic and histamine (h1) receptors
What is citalopram metabolised by?
CYP2C19
What is fluxotine a mild antagonist of?
5HT2A and 5HT2C receptors
What does fluxotine completely inhibit?
CYP2D6
What does fluxotine significantly inhibit?
CYP2C19
What drug must you take caution with when prescribing fluxotine?
Warfarin
What is the mechanism of action of venlaflaxine?
Inhibits reuptake of serotonin and noradrenaline (but serotonin a lot more)
What are the main side effects of venlaflaxine?
Insomnia, GI effects, hypertension at higher doses, anxiety, sexual dysfunction
What is the mechanism of action of mirtazipine?
Antagonist of central presynaptic alpha-2-adrenergic receptors, which causes increased release of serotonin and noradrenaline as it leaves 5HT1 receptors unapposed
What are the main side effects of mirtazipine?
Weight gain and sedation
What are some side effects of mirtazipine?
May exacerbate REM sleep and cause behaviour disorder
Sexual dysfunction may occur but there’s a low probability
