Pharmacology of Diabetes

Question 1

What are the 4 main drugs we can prescribe for diabetics?

Answer 1

Metformin
DDP-4 inhibitor
Sulphonylureas
SGLT-2 inhibitors

Question 2

What is the primary drug target for metformin?

Answer 2

AMP activated protein kinase

Question 3

What is the primary drug target for DPP-4 inhibitors?

Answer 3

DPP-4

Question 4

What is the primary drug target for sulphonylureas?

Answer 4

ATP sensitive K+ channels

Question 5

What is the primary drug target for SGLT-2 inhibitors?

Answer 5

SGLT-2

Question 6

What is the drug target type for metformin?

Answer 6

Enzyme

Question 7

What is the drug target type for DPP-4?

Answer 7

Enzyme

Question 8

What is the drug target type for sulphonylureas?

Answer 8

Ion channels

Question 9

What is the drug target type for SGLT-2 inhibitors?

Answer 9

Transport proteins

Question 10

What location does metformin work at?

Answer 10

Hepatocyte mitochondria

Question 11

What location does DPP-4 inhibitor work at?

Answer 11

Vascular endothelium

Question 12

What location does sulphonylurea work at?

Answer 12

Pancreatic beta cells

Question 13

What location does SGLT-2 inhibitor work at?

Answer 13

PCT

Question 14

What is the action of metformin?

Answer 14

Decreased gluconeogenesis

Question 15

What is the action of DPP-4 inhibitor?

Answer 15

Increased plasma incretin levels

Question 16

What is the action of sulphonylureas?

Answer 16

Insulin secretion

Question 17

What is the action of SGLT-2 inhibitors?

Answer 17

Decreased glucose reabsorption