Pharmacology of GORD Flashcards
What is the mechanism of action of NSAIDs?
They inhibit the COX 2 enzyme stopping production of prostanoids
What are the common NSAIDs?
Ibuprofen, naproxen, diclofenac
What are NSAIDs used for?
Anti inflammatory actions
What do NSAIDs act on the produce unwanted effects?
COX 1 enzyme
What are side effects of NSAIDs?
Gastric irritation
Ulceration
Bronchoconstriction
Adverse cardiovascular effects
What are the main PPIs?
Omeprazole, lansoprazole
What is the mechanism of action for PPIs?
They irreversibly inhibit H+/K+ ATPase in gastric parietal cells reducing secretion of gastric acid
What are side effects of PPIs?
Headache Diarrhoea Bloating Abdominal pain Rashes
What might omeprazole mask the effect of?
Clopidrogel
What is the main histamine receptor antagonist?
Ranitidine
What is the mechanism of action of histamine receptor antagonists?
They block histamine receptors inhibiting histamine release in gastric parietal cells reducing gastric acid secretion
What are side effects of histamine receptor antagonists?
Diarrhoea
Dizziness
Muscle pain
What is done if a patient develops gastric side effects from NSAIDs?
Stop NSAID use if possible
Give a 4-8 week course of PPIs
Why can’t PPIs be given if someone has osteoperosis? What is given instead?
PPIs increase the risk of fractures, a histamine receptor antagonist is given instead
