Angina and MI Flashcards
What are the differential diagnoses for chest pain?
Pulmonary
Cardiovascular
Musculoskeletal
What does typical angina present with?
All three of the features:
Precipitated by physical exertion
Constricting discomfort in the front of the chest, in the neck, shoulders, jaw, or arms
Relieved by rest or glyceryl trinitrate (GTN) within about 5 minutes
What does atypical angina present with?
2 of the 3 features for typical angina along with atypical symptoms like GI discomfort, breathlessness or nausea
What features are likely to lead to a diagnosis of stable angina?
Pain that is continuous or prolonged.
Pain that is unrelated to activity.
Pain that is brought on by breathing.
Pain that is associated with dizziness, palpitations, tingling, or difficulty swallowing
What are the different types of angina?
Stable
Unstable
Variant (prinzmetal)
How long does stable angina usually last?
Under 5 mins
How long does unstable angina usually last?
Longer than 5 mins, can be prolonged
What type of angina is relievable by medicine?
Stable angina
What type of angina can lead to MI?
Unstable
What is pain inn variant angina caused by?
A spasm in the coronary arteries caused by exposure to cold, stress, smoking etc
What are some risk factors for angina?
Alcohol use Tobacco use High BP Family history Gender
What are some tests performed for angina clinically?
ECG Coronary angiography Exercise tolerance test Lab tests Troponin
What are troponin levels after heart damage?
They are elevated within a few hours of heart damage and remain elevated for up to two weeks
If troponin is normal, what is likely the pain is caused by and what is it less likely the pain is caused by?
More likely that the pain is due to stable angina
Less likely that the symptoms and chest pain are due to heart muscle damage
What are first line treatments for stable angina?
Short acting nitrates with beta blocker or CCB
Other options if heart rate is low or if symptoms remain uncontrolled
What type of MI occurs if the LCA and LAD are involved?
Anterior
What type of MI occurs if the LCx is involved?
Lateral
What type of MI occurs if the RCA is involved?
Inferior
What type of MI occurs if the RCA and LCx are Involved?
Posterior
What type of MI occurs if the LAD is involved?
Septal
In anterior MI where is ST segment elevation found?
V1-V4
In lateral MI where is ST segment elevation found?
I, avL, V5, V6
In inferior MI where is ST segment elevation found?
II, III, aVF
In posterior MI where is ST segment elevation found?
V7-V9
In septal MI where is ST segment elevation found?
V1 and V2
What type of angina is STEMI?
Stable
What is the management for STEMI?
Antiplatelet and add-on anti-ischemic/anticoagulant treatment
Reperfusion therapy (first line: primary PCI), alternative only if PCI unavailable, thrombolysis (if within the window) or rescue PCI if thrombolysis fails or CABG)
Long-term management
What happens to the ST segment in STEMI vs NSTEMI
STEMI= ST segment elevation NSTEMI= ST segment depression and T wave inversion
What is the main difference between STEMI and NSTEMI?
Pathophysiology:
STEMI= nearly always coronary plaque rupture resulting in thrombosis formation occluding a coronary artery
NSTEMI= incomplete thrombus formation
What does incomplete thrombus formation is NSTEMI cause?
Blood and oxygen is not completely stopped but the restriction is so great that the oxygen content is used up quickly
In the distal arteries and arterioles, tissue death occurs as a result of oxygen starvation
The area affected is small, not enough to cause ST elevation but enough to cause minor ST/T wave changes and troponin elevation
Describe the lumen in STEMI vs NSTEMI
STEMI= completely blocked, no oxygen supply to tissue NSTEMI= only partially blocked, even if plaque is unstable and ruptures theres enough lumen to allow blood flow that meets oxygen demand during rest
What are the 2 acute coronary syndrome types and how are they differentiated on ECG?
STEMI= will have ST elevation NSTEMI= no ST elevation
What is the difference between unstable angina and NSTEMI
NSTEMI= raised troponins
Unstable angina= normal troponins
How do we decide how to treat unstable angina/ NSTEMI?
Perform a risk assessment
If they are low risk do a stress test and if positive do coronary angiography
If they are high risk invasive management is need eg CA, CABG, PCI