Rheumatoid Arthritis Pathophysiology Flashcards
Signs of RA?
Morning stiffness
Swelling, heat, redness and pain,
Loss of function
Multiple joints in a symmetrical fashion
Features of RA?
3x more women than men
Prevalence?
Affects 1%
Autoantibodies?
Cyclic citrulinated peptide and rheumatoid factor
Cytokines in RA?
IL 1/ 6 and TNF alpha
IL6 triggers liver for acute phase response
And stimulates adipocytes leading to diabetes
Comorbidities of RA?
MI Stroke Atherogenesis Low stress tolerance Depression Fractures
Where do the antibodies bind?
Fc portion of igM, igG
Autoantibodies are found in how many patients?
60-70%
How specific are the antibodies for RA?
86%
Patients positive with the antibodies are….?
Have a more severe disease
Antibodies against CCp are found in patients percentage?
70-80%
Antibodies detect?
Arginine to citrulline change
Fibronectin, collagen
Mechanism of anti citrullinated antibodies?
Activation of inflammatory cells by anti CCP immune complexes
Bind to osteoclast
Producing NETs
Monozygotic identicals getting RA?
12-15%
Dizygotic non-identical chances of getting RA?
2-5%