Mucosal Immunity Flashcards
MUCOSA ASSOCIATED LYMPHATIC TISSUE IS DIVIDED INTO
Bronchus associated lymphatic tissue
Gut associated lymphatic tissue
Surface area of mucosa?
400m2 60% of effector cells
Endogenous flora number is?
10 to power of 14- x10 more than human body cells
Regionalised immune system?
Peyer’s patches
Waldeyer’s ring ( lingual, palatine and nasopharyngeal tonsils)
Microbiota?
Actual microorganisms
Microbiome?
Totality of their genes
Healthy food increase?
Mucus secretion and antimicrobial peptides
Unhealthy food cause>
Enhance mucus degradation
Reduce antimicrobial peptides
What is the function of mucus?
Keep bacteria away from epithelium
Prudent diet gives rise to?
Rich in fibre
Production of SCFA by bacteria
Increase mucus production
Increased expression of tight junction proteins
On basolateral surface of gut which TLR do you have?
5 and it tightens tight junction upon contact with bacteria
What is NLR in cytoplasm activated by?
Flagellins ( invading bacteria)
Paneth cell produce?
Defensins 5 and 6 and trypsin
What does trypsin do?
Activates human Defensin 5 and 6 by proteolytic cleavage
What is in the mucus?
Antibacterial peptides and antibodies of IgG and igA