Pharmacological Aspects Of Immunology Flashcards
Where does aspirin come from?
White willow
Used to treat fever and joint pain
Prostacyclins govern?
Vasodilatation
How many scripts for NSAIDS each year in UK?
25 million
Aspirin usage limited by?
GI toxicity
Tinnitus
Reye’s syndrome
What Is aspiring used for?
Anti-platelet effect, prevention of stroke and mi
COX2 is induced in
Inflammation
Cox 1 is?
Expressed in all tissues
Hence inhibtion will result in anti platelet activity
Cox 3 possibly only found in?
CNS
How many people use no prescription NSAIDs?
20-30
Aspirin limited for?
Tinnitus
Reye’s syndrome (hepatic failure in children)
GI toxicity
What is aspirin good for?
Anti platelet effect stroke and MI, prevention and treatment
Why GI toxicity in NSAID?
Prostaglandins E2 and I2, decrease acid production, increase mucus production and blood supply, which is inhibited by NSAID
NSAID in GI can cause
Ulcers
Bleeding
Irritation
Relative risk of upper GI bleeding with NSAID?
4.7
Which NSAID has a relative risk of 23.5 for bleeding?
Azapropazone