Overview Of Immunology Flashcards
NK cells are?
Both innate and adaptive
Neutrophil appearance?
Granulosed cytoplasm and multi lobed nucleus
Eosinophil role?
Parasitic infection/ helminth
Monocytes role?
Phagocytosis antigen presentation
Dendritic cells appearance?
Long processes, role of antigen presentation
Lymphocyte appearance?
Big nucleus, little cytoplasm
What does lymph drain into?
Subclavian duct
Juxtacrine?
Signalling cell and target cell bind together
Cytokine?
Small proteins released by cells that have an effect on another cell
Chemokines definition?
Similar to cytokines, by main role in temporal and spatial organisation of cells and tissue, different structure receptors and nomenclature
Innate antigen receptors?
Don’t recognise antigen specifically but
Pattern recognition receptors
Which recognise pathogen associated molecular patterns PAMPS
Not clonally distributed, same on every cell with the receptor
Mannose binding ligand bind to?
Mannose and fucose residues with correct spacing, lower organisms usually on fungi
How are adaptive antigen receptors made?
Random somatic recombination events between gene segments
T cell receptor made of?
Alpha and beta chain, with constant and variable region, not secreted it is fixed. Recognise processed antigens in the form of linear peptides
What percent of vdj are junk?
90%
T cell recognise peptide by?
MHC presenting the peptide
Class 2 MHC
Antigen endocytosed Then processed into peptides into a phagocytes-lysosome Which bind to mhc 2 molecule Which is exocytosed Then T cell binds to it
Class MHC1
Viral proteins produced by cells
Proteins go into proteasome
Then broken down into peptides attached by TAP transporter, which transports cytosolic peptides into ER, where they bind to MHC 1.
Exocytosed, Presented onto cell surface
Eosinophils look?
2 lobed non segmented nucleus with large granules, typically looking red
Basophils in tissue becomes?
Mast cell
What do NK cells do?
Direct lysis of infected cells and antibody dependent cellular cytotoxicity
Where are MHC molecules created?
Ribosomes
