MT2 Flashcards
What is the role of the serum protein properdin in the complement system?
Increases the half-life of the C3 convertase (C3bBb) in the alternative pathway by protecting it from proteases
What are the 2 isotopes of immunoglobulin expressed by naive B cells?
IgM and IgD
Outline the 2 major steps that take place in the thymus that lead to central T cell tolerance?
Positive selection of T cells in the thymus of cells which can bind MHC
Negative selection of T cells which can bind self antigen or have high affinity for self MHC
2 mechanisms through which peripheral cell tolerance is achieved?
T cell ignorance
T cells which are suppressed by Treg cells
Anergy of T cells which have TCRs which bind presented antigen without accessory molecules
T cell apoptosis induced by repeated stimulation of the TCR in a non-inflammatory environment
Q5 in photos
Autoimmune diseases where pathogens is is definitely directly mediated by a pathogenic antibody?
Graves’ disease Myasthenia gravis Pernicious anaemia Autoimmune cytopenia of any type Chronic spontaneous urticaria
3 proven strategies for preventing HIV infection?
Sexually transmitted infections treatment Circumcision Antiretroviral treatment PEP/PREP Expansion of HIV testing Abstinence Avoid breast feeding Screening blood donors Needle exchange
Why would injury to musculocutaneous nerve weaken supination?
MSK innervated biceps which is involved in supination
Role of lumbricals in forming a precision grip?
Flexion of MCP and extension of interphalangeal joints or precision grip
