Adaptive Immune System 1 Flashcards

1
Q

B cells express antigens like?

A

CD19

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2
Q

Cells express antigens such as?

A

CD3 CD4 CD8

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3
Q

T helper cell division?

A

Th1
Th2
Th17
Treg

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4
Q

B cells develop in?

A

Stromal cells in bone marrow

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5
Q

Average life expectancy of naive B cell?

A

5 days

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6
Q

In adults what happens to thymus?

A

Some residual corticomedullary tissue with thymocytes

New T cells generated in extrathymic sites

Long lived peripheral T cell pool

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7
Q

Which cells die or remain?

A

Negative and positive selection

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8
Q

What are common stages of b and T cell development?

A
  1. Generation of antigen receptor
  2. Refinement of the antigen receptor repertoire (positive and negative selection)
  3. Stimulation by foreign antigen
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9
Q

Thymus dependent antigen?

A

Dependent upon t helper cells to induce antibody production e.g protein

Most igM

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10
Q

Thymus independent antigens example?

A

Polysaccharides and lipids

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11
Q

B cells are activated by?

A

Direct BCR cross linking

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12
Q

B cells often require a second activation signalling through?

A

Toll like receptor engagement

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13
Q

Signalling complex in membrane for B cell is?

A

Ig alpha and igbeta

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14
Q

Signalling complex for T cell membrane?

A

Cd3

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15
Q

B and T cell interaction?

A

Signal 1 through antigen receptor

Signal 2 co stimulation

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16
Q

CD80/CD86 on B cell bind to?

A

CD28 on T cell providing signal 2 to T cell

17
Q

T cell activation leads to up regulation of what?

A

CD40L which binds to Cd40 providing signal 2 to B cell

Cytokines production by activated T cell can activate B cell signal 3