Adaptive Immune System 1 Flashcards
B cells express antigens like?
CD19
Cells express antigens such as?
CD3 CD4 CD8
T helper cell division?
Th1
Th2
Th17
Treg
B cells develop in?
Stromal cells in bone marrow
Average life expectancy of naive B cell?
5 days
In adults what happens to thymus?
Some residual corticomedullary tissue with thymocytes
New T cells generated in extrathymic sites
Long lived peripheral T cell pool
Which cells die or remain?
Negative and positive selection
What are common stages of b and T cell development?
- Generation of antigen receptor
- Refinement of the antigen receptor repertoire (positive and negative selection)
- Stimulation by foreign antigen
Thymus dependent antigen?
Dependent upon t helper cells to induce antibody production e.g protein
Most igM
Thymus independent antigens example?
Polysaccharides and lipids
B cells are activated by?
Direct BCR cross linking
B cells often require a second activation signalling through?
Toll like receptor engagement
Signalling complex in membrane for B cell is?
Ig alpha and igbeta
Signalling complex for T cell membrane?
Cd3
B and T cell interaction?
Signal 1 through antigen receptor
Signal 2 co stimulation
CD80/CD86 on B cell bind to?
CD28 on T cell providing signal 2 to T cell
T cell activation leads to up regulation of what?
CD40L which binds to Cd40 providing signal 2 to B cell
Cytokines production by activated T cell can activate B cell signal 3