Regulating Immunological Aspects

Question 1

What are cytokines actions?

Answer 1

Signalling by receptors depends on association with Janus kinases, tyrosine phosphorylation of signalling molecules.

Question 2

Cytokines are split into?

Answer 2

Type 1- IL
Type 2- IFN gamma Il 22
TNF
IL-1 Family Cytokines

Question 3

Cytokines pleiotropy?

Answer 3

The higher the pleiotropy the more cell types or tissues are targeted

Question 4

Cytokines redundancy?

Answer 4

Different cytokines have the same effects

Question 5

Endothelial cells produce?

Answer 5

IL6, causing inflammatory cells to be activated, fever and acute phase protein production in the liver

Question 6

Haptotaxis?

Answer 6

Migration following a gradient of increasing conc of immobilised molecules

Question 7

Chemokinesis?

Answer 7

Increased movement by soluble chemokine

Question 8

Haptokinesis?

Answer 8

Increase of movement induced by immobilised chemokines

Question 9

Chemokines contain?

Answer 9

4 cysteine

Question 10

Names of chemokines are determined by?

Answer 10

Spacing between first 2 determines

Question 11

For blunt chest trauma severity measure?

Answer 11

IL3/13/21

Question 12

Inflammation and newborn sepsis and chorioamnionitis diagnostic use through?

Answer 12

IL6/ IL8

Question 13

Therapeutic use of melanoma use?

Answer 13

IL 2

Question 14

Homing to skin which cytokine interaction?

Answer 14

CXCR3 of Th1 CD4 T cells interacts with CXCL9 on endothelial cells

Question 15

Homing to gut lamina propria cytokine interaction?

Answer 15

Th1 CD4 T cell CCL25 acts on CR9 on endothelial cells

Question 16

How do chemokines interact at receptor?

Answer 16

G - protein coupled chemokine receptors

Question 17

What is the diagnostic use of IL 1 beta?

Answer 17

Inflammation, ventilator associated pneumonia

Question 18

What is the diagnostic use of il 3 13 and 21?

Answer 18

Blunt chest trauma severity

Question 19

What is the diagnostic use of il 6 and 8?

Answer 19

Inflammation sepsis and chroioamnionitis

Question 20

What is the diagnostic use of il 10?

Answer 20

Large B cell lymphoma

Question 21

What is the diagnostic use of interferon gamma?

Answer 21

Tb

Question 22

Which interleukin has therapeutic use for psoriasis?

Answer 22

Il 10

Question 23

Which cytokine has therapeutic use for viral hepatitis, cancer and tuberculosis?

Answer 23

IFN alpha

Question 24

Which interleukin has therapeutic use for il 2?

Answer 24

Melanoma, renal cell carcinoma

Question 25

Which cytokine has diagnostic use for macrophage activation in CGD chronic granulomatous diseasE?

Answer 25

IFN gamma

Question 26

Which is a cytokine antagonist for therapeutic use in rheumatoid arthritis?

Answer 26

Anti TNF