Regulating Immunological Aspects Flashcards
What are cytokines actions?
Signalling by receptors depends on association with Janus kinases, tyrosine phosphorylation of signalling molecules.
Cytokines are split into?
Type 1- IL
Type 2- IFN gamma Il 22
TNF
IL-1 Family Cytokines
Cytokines pleiotropy?
The higher the pleiotropy the more cell types or tissues are targeted
Cytokines redundancy?
Different cytokines have the same effects
Endothelial cells produce?
IL6, causing inflammatory cells to be activated, fever and acute phase protein production in the liver
Haptotaxis?
Migration following a gradient of increasing conc of immobilised molecules
Chemokinesis?
Increased movement by soluble chemokine
Haptokinesis?
Increase of movement induced by immobilised chemokines
Chemokines contain?
4 cysteine
Names of chemokines are determined by?
Spacing between first 2 determines
For blunt chest trauma severity measure?
IL3/13/21
Inflammation and newborn sepsis and chorioamnionitis diagnostic use through?
IL6/ IL8
Therapeutic use of melanoma use?
IL 2
Homing to skin which cytokine interaction?
CXCR3 of Th1 CD4 T cells interacts with CXCL9 on endothelial cells
Homing to gut lamina propria cytokine interaction?
Th1 CD4 T cell CCL25 acts on CR9 on endothelial cells
How do chemokines interact at receptor?
G - protein coupled chemokine receptors
What is the diagnostic use of IL 1 beta?
Inflammation, ventilator associated pneumonia
What is the diagnostic use of il 3 13 and 21?
Blunt chest trauma severity
What is the diagnostic use of il 6 and 8?
Inflammation sepsis and chroioamnionitis
What is the diagnostic use of il 10?
Large B cell lymphoma
What is the diagnostic use of interferon gamma?
Tb
Which interleukin has therapeutic use for psoriasis?
Il 10
Which cytokine has therapeutic use for viral hepatitis, cancer and tuberculosis?
IFN alpha
Which interleukin has therapeutic use for il 2?
Melanoma, renal cell carcinoma
