Respiratory Embryology Flashcards
Where does the respiratory system begin its growth?
Median outgrowth of laryngotracheal groove
What happens to the outgrowth of laryngotracheal groove?
The groove evaginates to form the laryngotracheal diverticulum that will elongate
What forms at the distal end of the laryngotracheal diverticulum?
Respiratory bud
The respiratory bud is the origin of?
Respiratory tree
What develop to form the tracheoesophageal septum?
Tracheoesophageal folds
What do the tracheoesophageal folds cause to happen?
Splits the foregut into ventral and dorsal portions
- ventral = laryngotracheal tube
- dorsal = esophagus
What creates the pulmonary epithelium and glands of the trachea, larynx and bronchi?
Endoderm of laryngotracheal groove
What creates the cartilage, smooth muscle and CT of the trachea, larynx and bronchi?
Splanchnic lateral plate mesoderm
What pharyngeal arches contribute to larynx and laryngeal muscle development?
4 and 6
For the development of the larynx, mesenchyme produces?
Arytenoid swellings
What do the arytenoid swellings do?
Convert the primordial glottis into a T-shaped laryngeal inlet
After the arytenoid swellings for the T-shaped laryngeal inlet, what occurs to the laryngeal epithelium?
It proliferates and blocks the lumen of the larynx
Recanalization of the larynx occurs by what week?
10th
During recanalization of the larynx, what form that are bounded by mucous membranes?
Vocal and vestibular folds
In a neonate, what is the epiglottis in contact with?
Soft palate
How old is someone if their larynx is very high up?
Less than 2 years old
Laryngeal descent occurs when?
Over first 2 years of life
Laryngeal atresia
Failure of recanalization of the larynx
“CHAOS” - congenital high airway obstruction syndrome
What are the symptoms of laryngeal atresia?
Lungs enlarged and filled with fluid
Airways dilated
Diaphragm flattened